CXCR7 suppression modulates microglial chemotaxis to ameliorate experimentally-induced autoimmune encephalomyelitis

doi:10.1016/j.bbrc.2015.11.059

科研成果详情

题名	CXCR7 suppression modulates microglial chemotaxis to ameliorate experimentally-induced autoimmune encephalomyelitis
作者	Bao, Jianhong1; Zhu, Jinying 2; Luo, Sheng3; Cheng, Ying1; Zhou, Saijun1
发表日期	2016
发表期刊	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	CXCR7 Microglia Chemotaxis Experimentally-induced autoimmune encephalomyelitis (EAE) Extracellular signal-regulated kinase (ERIC)
其他关键词	CHEMOKINE RECEPTOR ; MULTIPLE-SCLEROSIS ; CELL-SURVIVAL ; T-CELLS ; INDUCTION ; ACTIVATION ; CXCL12 ; SDF-1
摘要	Multiple sclerosis (MS) is the prototypical inflammatory demyelinating disease of the central nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE), widely used as an animal model of MS, classically manifests as an ascending paralysis that is characterized by extensive infiltration of the CNS by inflammatory cells. Although several studies uncover the significant role of microglia in the development of EAE, the cellular mechanisms of microglia that govern EAE pathogenesis remain unknown. In the current study, we report that CXCR7 expression is dynamic regulated in activated microglia during CNS autoimmunity and positively correlates with the clinical severity of EAE. In addition, microglial chemotaxis is mediated by CXCR7 during CNS autoimmunity, signaling through extra cellular signal-regulated kinase (ERK)1/2 activation, whereas p38 mitogen-activated protein kinase (MAPK) and (c-Jun N-terminal kinase) JNK are not involved. Most importantly, CXCR7 neutralizing treatment ameliorates the clinical severity of EAE along with ERK1/2 phosphorylation reduction. Collectively, our data demonstrate that CXCR7 suppression modulates microglial chemotaxis to ameliorate EAE. (C) 2015 Elsevier Inc. All rights reserved.
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
出版地	SAN DIEGO
ISSN	0006-291X
EISSN	1090-2104
卷号	469 期号:1 页码:1-7
DOI	10.1016/j.bbrc.2015.11.059
页数	7
WOS类目	Biochemistry & Molecular Biology ; Biophysics
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS记录号	WOS:000368868000001
收录类别	SCIE ; PUBMED
URL	查看原文
PubMed ID	26607112
通讯作者地址	[Zhou, Saijun]Wenzhou Med Coll, Affiliated Hosp 1, Dept Neurol, Wenzhou 325000, Peoples R China.
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/13532
专题	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科附属第一医院附属第一医院_精神卫生科
通讯作者	Zhou, Saijun
作者单位	1.Wenzhou Med Coll, Affiliated Hosp 1, Dept Neurol, Wenzhou 325000, Peoples R China; 2.Wenzhou Med Coll, Affiliated Hosp 1, Dept Mental Hlth, Wenzhou 325000, Peoples R China; 3.Wenzhou Med Coll, Affiliated Hosp 1, Dept Hematol, Wenzhou 325000, Peoples R China
第一作者单位	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
通讯作者单位	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
第一作者的第一单位	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
推荐引用方式 GB/T 7714	Bao, Jianhong,Zhu, Jinying,Luo, Sheng,et al. CXCR7 suppression modulates microglial chemotaxis to ameliorate experimentally-induced autoimmune encephalomyelitis[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2016,469(1):1-7.
APA	Bao, Jianhong, Zhu, Jinying, Luo, Sheng, Cheng, Ying, & Zhou, Saijun. (2016). CXCR7 suppression modulates microglial chemotaxis to ameliorate experimentally-induced autoimmune encephalomyelitis. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 469(1), 1-7.
MLA	Bao, Jianhong,et al."CXCR7 suppression modulates microglial chemotaxis to ameliorate experimentally-induced autoimmune encephalomyelitis".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 469.1(2016):1-7.