High fibrinogen-to-albumin ratio is associated with hemorrhagic transformation in acute ischemic stroke patients

doi:10.1002/brb3.1855

科研成果详情

题名	High fibrinogen-to-albumin ratio is associated with hemorrhagic transformation in acute ischemic stroke patients
作者	Ruan, Yiting 1; Yuan, Chengxiang 1; Liu, Yuntao 1; Zeng, Yaying 2; Cheng, Haoran 1; Cheng, Qianqian 2; Chen, Yunbin 1; Huang, Guiqian1; He, Weilei 1; He, Jincai1
发表日期	2021-01
发表期刊	BRAIN AND BEHAVIOR 影响因子和分区
语种	英语
原始文献类型	Article
关键词	acute ischemic stroke albumin fibrinogen hemorrhagic transformation inflammation
其他关键词	BLOOD-BRAIN-BARRIER ; SERUM-ALBUMIN ; PROGNOSTIC-SIGNIFICANCE ; THROMBOLYTIC THERAPY ; INFARCTION ; MECHANISMS ; RISK
摘要	Introduction Hemorrhagic transformation (HT) is a complex and multifactorial complication among patients with acute ischemic stroke (AIS), and the inflammatory response has been considered as a risk factor for HT. We aimed to evaluate the stratification of FAR (fibrinogen-to-albumin ratio), an inflammatory biomarker, in HT patients. Methods A total of 256 consecutive stroke patients with HT and 256 age- and gender-matched stroke patients without HT were included in this study. HT during hospitalization was diagnosed by follow-up imaging assessment and was classified into hemorrhagic infarction (HI) and parenchymal hematoma (PH) according to the recommendations of European Cooperative Acute Stroke Study II classification. Blood samples were obtained at admission. Results Higher levels of FAR were observed in patients with HT compared with the non-HT group [10.29 (8.39-12.95) vs. 8.60 (7.25-10.8), p < .001], but no significant difference was found between the PH and HI [10.88 (8.72-13.40) vs. 10.13 (8.14-12.60), p > .05]. Patients were assigned to groups of high FAR (>= 9.51) and low FAR (<9.51) based on the optimal cut-off value. After adjustment for potential confounders, the high FAR remained independently associated with the increased risk of HT (OR = 5.027, 95% CI = 5.027 (2.309-10.942), p < .001). Conclusions High FAR was independently associated with the increased risk of HT after AIS.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81873799]
出版者	WILEY
出版地	HOBOKEN
ISSN	2162-3279
卷号	11 期号:1 页码:e01855.
DOI	10.1002/brb3.1855
页数	9
WOS类目	Behavioral Sciences ; Neurosciences
WOS研究方向	Behavioral Sciences ; Neurosciences & Neurology
WOS记录号	WOS:000597760800001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	33314645
PMC记录号	PMC7821560
SCOPUSEID	2-s2.0-85097406660
通讯作者地址	[He, Jincai]Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Behavioral Neuroscience
引用统计	被引频次：9[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/13446
专题	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_精神病与精神卫生学_精神卫生科
通讯作者	He, Jincai
作者单位	1.Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Department of Mental Health,Mental Health School,Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Ruan, Yiting,Yuan, Chengxiang,Liu, Yuntao,et al. High fibrinogen-to-albumin ratio is associated with hemorrhagic transformation in acute ischemic stroke patients[J]. BRAIN AND BEHAVIOR,2021,11(1):e01855..
APA	Ruan, Yiting., Yuan, Chengxiang., Liu, Yuntao., Zeng, Yaying., Cheng, Haoran., ... & He, Jincai. (2021). High fibrinogen-to-albumin ratio is associated with hemorrhagic transformation in acute ischemic stroke patients. BRAIN AND BEHAVIOR, 11(1), e01855..
MLA	Ruan, Yiting,et al."High fibrinogen-to-albumin ratio is associated with hemorrhagic transformation in acute ischemic stroke patients".BRAIN AND BEHAVIOR 11.1(2021):e01855..