Low serum 25-hydroxyvitamin D concentrations in chronic insomnia patients and the association with poor treatment outcome at 2 months

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题名	Low serum 25-hydroxyvitamin D concentrations in chronic insomnia patients and the association with poor treatment outcome at 2 months
作者	Kai Zhao ; Xiaoqian Luan; Yuntao Liu; Xinjie Tu ; Huijun Chen ; Huiping Shen ; Huihua Qiu ; Zhuoying Zhu ; Jincai He
发表日期	2018-06-29
会议录名称	中国睡眠研究会第十届全国学术年会汇编影响因子和分区
语种	英语
原始文献类型	中国会议
关键词	Chronic insomnia Vitamin D Outcome
摘要	Background: The association between low 25-hydroxyvitamin D [25(OH)D] and sleep disorder has been reported.We investigated whether serum concentrations of 25(OH)D are altered in chronic insomnia patients.The relationship between serum concentrations of 25(OH)D and the treatment outcome in patients at 2 months was also investigated.Methods: In total,181 chronic insomnia patients were consecutively recruited.All patients received pharmacotherapy for the treatment of chronic insomnia.Serum 25(OH)D concentrations were quantified by a competitive electrochemiluminescence protein binding assay.Treatment outcomes were defined as "response" versus"non-response",according to the change of the Pittsburgh Sleep Quality Index(PSQI).We also recruited 100 healthy subjects as a control group.Results: Fifty-four out of 181(29.8%) patients met the criteria for non-response.Chronic insomnia patients had significantly lower 25(OH)D concentrations compared with healthy controls(23.01 ± 9.18 vs27.17 ± 6.41 ng/ml,P < 0.001).Non-response patients also had significantly lower 25(OH)D concentrations than those with response.Vitamin D deficiency(25(OH)D concentrations < 20 ng/ml) was independently associated with a higher probability of treatment non-response at 2 months(odds ratio 11.636,95% confidence interval 3.966–34.142,P < 0.001).Conclusions: Measurement of serum 25(OH)D concentrations are probably useful for judging treatment outcomes of pharmacotherapy in chronic insomnia patients.
资助项目	supported by a grant from Wenzhou Municipal Sci-Tech Bureau Program (Y20160002);; National Key Technology Research and Development Program of the Ministry of Science and Technology of the People's Republic of China (grant number: 2015BAI13B01)
页码	5
收录类别	CNKI
文献类型	会议论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/134309
专题	附属第一医院
作者单位	1.Department of Neurology 2.The First Affiliated Hospital of Wenzhou Medical University
推荐引用方式 GB/T 7714	Kai Zhao,Xiaoqian Luan,Yuntao Liu,et al. Low serum 25-hydroxyvitamin D concentrations in chronic insomnia patients and the association with poor treatment outcome at 2 months[C],2018:5.

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