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题名 | Helicobacter pylori infection with atrophic gastritis: An independent risk factor for colorectal adenomas |
作者 | |
发表日期 | 2020-10-07 |
发表期刊 | World Journal of Gastroenterology 影响因子和分区 |
语种 | 英语 |
关键词 | Helicobacter pylori Gastritis Atrophy Adenomas Colorectal Health-check |
摘要 | BACKGROUND The significance of Helicobacter pylori(H. pylori) infection and atrophic gastritis(AG) in the prevalence of colorectal adenomas has been examined in a limited number of studies. However, these studies reported disputed conclusions.AIM To investigate whether H. pylori infection, AG, and H. pylori-related AG increase the risk of colorectal adenomas.METHODS This retrospective cross-sectional study included 6018 health-check individuals. The relevant data for physical examination, laboratory testing, 13 C-urea breath testing, gastroscopy, colonoscopy and histopathological examination of gastric and colorectal biopsies were recorded. Univariate and multivariate logistic regression analyses were performed to determine the association between H. pylori-related AG and colorectal adenomas.RESULTS Overall, 1012 subjects(16.8%) were diagnosed with colorectal adenomas, of whom 143(2.4%) had advanced adenomas. Among the enrolled patients, the prevalence of H. pylori infection and AG was observed as 49.5%(2981/6018) and 10.0%(602/6018), respectively. Subjects with H. pylori infection had an elevated risk of colorectal adenomas(adjusted odds ratio [OR] of 1.220, 95% confidence interval (CI): 1.053-1.413, P = 0.008) but no increased risk of advance adenomas(adjusted OR = 1.303, 95%CI: 0.922-1.842, P = 0.134). AG was significantly correlated to an increased risk of colorectal adenomas(unadjusted OR = 1.668, 95%CI: 1.352-2.059, P < 0.001; adjusted OR = 1.237, 95%CI: 0.988-1.549, P = 0.064). H. pylori infection accompanied by AG was significantly associated with an increased risk of adenomas(adjusted OR = 1.491, 95%CI: 1.103-2.015, P = 0.009) and advanced adenomas(adjusted OR = 1.910, 95%CI: 1.022-3.572, P = 0.043).CONCLUSION H. pylori-related AG was associated with a high risk of colorectal adenomas and advanced adenomas in Chinese individuals. |
ISSN | 1007-9327 |
卷号 | 26期号:37页码:5682-5692 |
收录类别 | CNKI |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/134210 |
专题 | 附属第一医院_体检中心 附属第一医院 |
作者单位 | 1.Department of Physical Examination Medical Care Center,The First Affiliated Hospital of Wenzhou Medical University 2.Department of Cardiovascular Medicine,The Key Laboratory of Cardiovascular Diseases of Wenzhou,The First Affiliated Hospital of Wenzhou Medical University |
推荐引用方式 GB/T 7714 | Qin-Fen Chen,Xiao-Dong Zhou,Dan-Hong Fang,et al. Helicobacter pylori infection with atrophic gastritis: An independent risk factor for colorectal adenomas[J]. World Journal of Gastroenterology,2020,26(37):5682-5692. |
APA | Qin-Fen Chen., Xiao-Dong Zhou., Dan-Hong Fang., En-Guang Zhang., Chun-Jing Lin., ... & Wei-Hong Lin. (2020). Helicobacter pylori infection with atrophic gastritis: An independent risk factor for colorectal adenomas. World Journal of Gastroenterology, 26(37), 5682-5692. |
MLA | Qin-Fen Chen,et al."Helicobacter pylori infection with atrophic gastritis: An independent risk factor for colorectal adenomas".World Journal of Gastroenterology 26.37(2020):5682-5692. |
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