Association between Hemoglobin Glycation Index and NAFLD in Chinese Nondiabetic Individuals

doi:10.1155/2019/8748459

科研成果详情

题名	Association between Hemoglobin Glycation Index and NAFLD in Chinese Nondiabetic Individuals
作者	Hu, Di-Shuang 1; Zhu, Sheng-Hao1; Li, Xu 2; Chen, Qin-Fen3; Lin, Chun-Jing3; Fang, Dan-Hong3; Wu, Jian-Sheng3
发表日期	2019-12-21
发表期刊	CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	FATTY LIVER-DISEASE ; BIOLOGICAL VARIATION ; HBA(1C)
摘要	Purpose. Limited studies have preliminarily identified a positive association between nonalcoholic fatty liver disease (NAFLD) and hemoglobin glycation index (HGI). However, this association has not been fully established. We aim to investigate the association between NAFLD and HGI in Chinese nondiabetic individuals and to construct a risk score based on HGI to predict a person's risk of NAFLD. Methods. After strict exclusion criteria, 5,903 individuals were included in this retrospective cross-sectional study. We randomly selected 1,967 subjects in the enrollment to obtain an equation of linear regression, which was used to calculate predicted HbA1c and drive HGI. The other subjects were classified into four categories according to HGI level (<=-0.22, -0.21 similar to 0.02, 0.03 similar to 0.28, and >= 0.29). All subjects retrospectively reviewed the baseline characteristics, laboratory examinations, and abdominal ultrasonography. Results. The prevalence of NAFLD in this population was 20.7%, which increases along with the growth of HGI levels (P<0.001). Adjusted to multiple factors, this trend still remained significant (OR: 1.172 (95% CI, 1.074-1.279)). The combined NAFLD risk score based on HGI resulted in an area under the receiver operator characteristic curve (AUROC) of 0.85 provided sensitivity, specificity, positive predictive value, and a negative predictive value for NAFLD of 84.4%, 71.3%, 65.0%, and 88.0%, respectively. Conclusions. NAFLD is independently associated with HGI levels in Chinese nondiabetic individuals. And, NAFLD risk score may be used as one of the risk predictors of NAFLD in nondiabetic population.
资助项目	Medical and Health Care Center of the First Affiliated Hospital of Wenzhou Medical University; Wenzhou Science and Technology Bureau [Y20180062]
出版者	HINDAWI LTD
出版地	LONDON
ISSN	2291-2789
EISSN	2291-2797
卷号	2019 页码:8748459
DOI	10.1155/2019/8748459
页数	8
WOS类目	Gastroenterology & Hepatology
WOS研究方向	Gastroenterology & Hepatology
WOS记录号	WOS:000522321300001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	31929982
PMC记录号	PMC6942793
SCOPUSEID	2-s2.0-85077463281
通讯作者地址	[Wu, Jian-Sheng]Medical and Health Care Center,First Affiliated Hospital of Wenzhou Medical University,Wenzhou , Zhejiang,325000,China
Scopus学科分类	Hepatology;Gastroenterology
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/13293
专题	附属第一医院仁济学院第一临床医学院（信息与工程学院）、附属第一医院_医疗保健中心
通讯作者	Wu, Jian-Sheng
作者单位	1.Department of Gastroenterology,First Affiliated Hospital of Wenzhou Medical University,Wenzhou , Zhejiang,325000,China; 2.Wenzhou Medical University RenJi College,Wenzhou, Zhejiang,325000,China; 3.Medical and Health Care Center,First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang,325000,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Hu, Di-Shuang,Zhu, Sheng-Hao,Li, Xu,et al. Association between Hemoglobin Glycation Index and NAFLD in Chinese Nondiabetic Individuals[J]. CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,2019,2019:8748459.
APA	Hu, Di-Shuang., Zhu, Sheng-Hao., Li, Xu., Chen, Qin-Fen., Lin, Chun-Jing., ... & Wu, Jian-Sheng. (2019). Association between Hemoglobin Glycation Index and NAFLD in Chinese Nondiabetic Individuals. CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2019, 8748459.
MLA	Hu, Di-Shuang,et al."Association between Hemoglobin Glycation Index and NAFLD in Chinese Nondiabetic Individuals".CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 2019(2019):8748459.