MicroRNA-329-3p targets MAPK1 to suppress cell proliferation, migration and invasion in cervical cancer

doi:10.3892/or.2017.5555

科研成果详情

题名	MicroRNA-329-3p targets MAPK1 to suppress cell proliferation, migration and invasion in cervical cancer
作者	Li, Wenfeng1,2; Liang, Jingjing 1,3; Zhang, Zhechao 1,3; Lou, Hongyan 1,3; Zhao, Liang 1,4; Xu, Yunsheng1,5; Ou, Rongying1,3
发表日期	2017-05
发表期刊	ONCOLOGY REPORTS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	microRNA-329-3p cervical cancer MAPK1 proliferation migration invasion target
其他关键词	HUMAN BREAST-CANCER ; DOWN-REGULATION ; MIR-329 SUPPRESSES ; SIGNALING PATHWAY ; HELA-CELLS ; IN-VITRO ; EXPRESSION ; GROWTH ; ERK1/2 ; GENES
摘要	Cervical cancer is the second most common gynecological cancer worldwide and remains as one of the leading causes of cancer-related death among women. Despite great progress in the treatment of cervical cancer, the 5-year overall survival rate for patients with this disease remains unsatisfactory. Over the past decade, an increasing number of studies indicate a central role for microRNAs in the initiation and progression of cervical cancer. microRNA-329-3p (miR-329-3p) has been studied in many types of human cancer; however, the expression level, biological role and the underlying mechanism of miR-329-3p in cervical cancer has not yet been investigated. In the present study, we found that the expression levels of miR-329-3p were reduced in both cervical cancer tissues and cell lines. Low miR-329-3p expression was negatively correlated with histological grade, International Federation of Gynecology and Obstetrics (FIGO) stage, and lymph node metastasis of cervical cancer patients. In addition, upregulation of miR-329-3p suppressed cell proliferation, migration and invasion of cervical cancer. Furthermore, MAPK1 was identified as a direct target gene of miR-329-3p. MAPK1 was significantly upregulated in cervical cancer tissues and was inversely correlated with miR-329-3p expression in the cervical cancer tissues. Silencing of MAPK1 by RNA interference mimicked the effects of miR-329-3p overexpression on cell proliferation, migration and invasion in cervical cancer. Moreover, rescue experiments showed that restoration of the expression of MAPK1 reversed the effects of miR-329-3p overexpression in cervical cancer cells. Taken together, these findings suggest that miR-329-3p has a critical tumor-suppressive roles by directly targeting MAPK1 in cervical cancer, and it may be investigated as a novel therapeutic target for the treatment of patients with this disease.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81571395, 81371748, 81373075]
出版者	SPANDIDOS PUBL LTD
出版地	ATHENS
ISSN	1021-335X
EISSN	1791-2431
卷号	37 期号:5 页码:2743-2750
DOI	10.3892/or.2017.5555
页数	8
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000400629500023
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	28393232
SCOPUSEID	2-s2.0-85018794105
通讯作者地址	[Ou, Rongying]Wenzhou Med Univ, Affiliated Hosp 1, Lab Adv Interdisciplinary Res, Ctr Personalized Med,Inst Translat Med, Wenzhou 325000, Zhejiang, Peoples R China.
引用统计	被引频次：48[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/13188
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_妇产科学
通讯作者	Ou, Rongying
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 1, Lab Adv Interdisciplinary Res, Ctr Personalized Med,Inst Translat Med, Wenzhou 325000, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Dept Radiat Oncol, Wenzhou 325000, Zhejiang, Peoples R China; 3.Wenzhou Med Univ, Dept Gynaecol & Obstet, Wenzhou 325000, Zhejiang, Peoples R China; 4.Wenzhou Med Univ, Dept Radiol, Div PET CT, Wenzhou 325000, Zhejiang, Peoples R China; 5.Wenzhou Med Univ, Affiliated Hosp 1, Dept Dermatovenereol, Wenzhou 325000, Zhejiang, Peoples R China
第一作者单位	附属第一医院; 温州医科大学
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Li, Wenfeng,Liang, Jingjing,Zhang, Zhechao,et al. MicroRNA-329-3p targets MAPK1 to suppress cell proliferation, migration and invasion in cervical cancer[J]. ONCOLOGY REPORTS,2017,37(5):2743-2750.
APA	Li, Wenfeng., Liang, Jingjing., Zhang, Zhechao., Lou, Hongyan., Zhao, Liang., ... & Ou, Rongying. (2017). MicroRNA-329-3p targets MAPK1 to suppress cell proliferation, migration and invasion in cervical cancer. ONCOLOGY REPORTS, 37(5), 2743-2750.
MLA	Li, Wenfeng,et al."MicroRNA-329-3p targets MAPK1 to suppress cell proliferation, migration and invasion in cervical cancer".ONCOLOGY REPORTS 37.5(2017):2743-2750.