MicroRNA-193a inhibits breast cancer proliferation and metastasis by downregulating WT1

doi:10.1371/journal.pone.0185565

科研成果详情

题名	MicroRNA-193a inhibits breast cancer proliferation and metastasis by downregulating WT1
作者	Xie, FeiYan 1; Hosany, Sumayyah 1; Zhong, Shen 1; Jiang, Yang 1; Zhang, Fen1; Lin, LiLi 1; Wang, XiaoBo1; Gao, ShenMeng2; Hu, XiaoQu 3
发表日期	2017-10-10
发表期刊	PLOS ONE 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	MULTI-CHEMORESISTANCE ; TUMOR-SUPPRESSOR ; HEPATOCELLULAR-CARCINOMA ; LUNG-CANCER ; MIR-193A-3P ; EXPRESSION ; APOPTOSIS ; PROMOTES ; GROWTH
摘要	In many cancers, microRNA-193a (miR-193a) is a suppressor miRNA, but its underlying anti-oncogenic activity in breast cancer is not known. In this study, we found decreased miR-193a (specifically, miR-193a-5p) expression not only in breast cancer cell lines but also in breast cancer tissues as compared with the adjacent non-tumor tissues. Ectopic miR-193a overexpression inhibited the proliferation, colony formation, migration, and invasion of MDA-MB-231 and BT549 cells. miR-193a reduced Wilms' tumor 1 (WT1) expression and repressed luciferase reporter activity by binding WT1 coding region sequences; mutation of the predicted miR-193a binding site abolished this effect. miR-193a and WT1 expression were significantly inversely correlated in breast cancer tissues. Importantly, the anti-cancer activity induced by miR-193a was partially reversed by WT1 overexpression, indicating an important role for WT1 in such activity related to miR-193a. Our results reveal that miR-193a-WT1 interaction plays an important role in breast cancer metastasis, and suggest that restoring miR-193a expression is a therapeutic strategy in breast cancer.
资助项目	Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81572580, 81672087]
出版者	PUBLIC LIBRARY SCIENCE
出版地	SAN FRANCISCO
ISSN	1932-6203
卷号	12 期号:10 页码:e0185565.
DOI	10.1371/journal.pone.0185565
页数	13
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
WOS记录号	WOS:000412627400023
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	29016617
PMC记录号	PMC5634539
SCOPUSEID	2-s2.0-85031025083
通讯作者地址	[Gao, ShenMeng]Laboratory of Internal Medicine,Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Multidisciplinary
引用统计	被引频次：48[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/13180
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_外科学_肿瘤外科
通讯作者	Gao, ShenMeng
作者单位	1.Wenzhou Medical University,Wenzhou,China; 2.Laboratory of Internal Medicine,Hospital of Wenzhou Medical University,Wenzhou,China; 3.Department of Surgical Oncology,Hospital of Wenzhou Medical University,Wenzhou,China
第一作者单位	温州医科大学
通讯作者单位	温州医科大学
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Xie, FeiYan,Hosany, Sumayyah,Zhong, Shen,et al. MicroRNA-193a inhibits breast cancer proliferation and metastasis by downregulating WT1[J]. PLOS ONE,2017,12(10):e0185565..
APA	Xie, FeiYan., Hosany, Sumayyah., Zhong, Shen., Jiang, Yang., Zhang, Fen., ... & Hu, XiaoQu. (2017). MicroRNA-193a inhibits breast cancer proliferation and metastasis by downregulating WT1. PLOS ONE, 12(10), e0185565..
MLA	Xie, FeiYan,et al."MicroRNA-193a inhibits breast cancer proliferation and metastasis by downregulating WT1".PLOS ONE 12.10(2017):e0185565..