miR-15a/16-1 enhances retinoic acid-mediated differentiation of leukemic cells and is up-regulated by retinoic acid

doi:10.3109/10428194.2011.601476

科研成果详情

题名	miR-15a/16-1 enhances retinoic acid-mediated differentiation of leukemic cells and is up-regulated by retinoic acid
作者	Gao, Shen-Meng1; Yang, Junjun3; Chen, Chiqi 1; Zhang, Shenghui1; Xing, Chong-Yun2; Li, Haiying 1; Wu, Jianbo1; Jiang, Lei1
发表日期	2011-12
发表期刊	LEUKEMIA & LYMPHOMA 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Retinoic acid miR-15a/16-1 differentiation leukemia
其他关键词	CHRONIC LYMPHOCYTIC-LEUKEMIA ; PROMYELOCYTIC LEUKEMIA ; TARGETING BCL2 ; MICRORNAS ; MIR-16-1 ; CANCER ; PROLIFERATION ; INDUCTION ; APOPTOSIS ; GENOMICS
摘要	miR-15a and miR-16-1 (miR-15a/16-1) have been implicated in apoptosis, cell cycle regulation and chemosensitivity of tumor cells, but little is known about the role of miR-15a/16-1 in the differentiation of leukemic cells. In this study, we found that the expression level of miR-15a/16-1 was up-regulated by all-trans retinoic acid (ATRA) treatment in NB4, HL-60 and U937 cell lines and primary leukemic cells. Overexpression of miR-15a/16-1 could not directly drive cells to undergo differentiation but enhanced ATRA-induced differentiation in NB4 and U937 cells. Up-regulation of miR-15a/16-1 was also observed in 36 patients with acute myeloid leukemia (AML) who achieved a complete remission (CR), and two of them showed sharp down-regulation of miR-15a/16-1 when they had a molecular relapse. These data indicate that miR-15a/16-1 plays an important role in the ATRA-induced differentiation of leukemic and primary AML cells.
资助项目	Zhejiang Provincial Education Department [Y201119952]
出版者	INFORMA HEALTHCARE
出版地	LONDON
ISSN	1042-8194
EISSN	1029-2403
卷号	52 期号:12 页码:2365-2371
DOI	10.3109/10428194.2011.601476
页数	7
WOS类目	Oncology ; Hematology
WOS研究方向	Oncology ; Hematology
WOS记录号	WOS:000297700900024
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	21838537
SCOPUSEID	2-s2.0-82255196136
通讯作者地址	[Jiang, Lei]Wenzhou Med Coll, Affiliated Hosp 1, Lab Internal Med, Wenzhou 325000, Zhejiang, Peoples R China.
引用统计	被引频次：27[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/13090
专题	附属第一医院附属第二医院_药物临床试验办公室
通讯作者	Jiang, Lei
作者单位	1.Wenzhou Med Coll, Affiliated Hosp 1, Lab Internal Med, Wenzhou 325000, Zhejiang, Peoples R China; 2.Wenzhou Med Coll, Affiliated Hosp 1, Dept Hematol, Wenzhou 325000, Zhejiang, Peoples R China; 3.Wenzhou Med Coll, Affiliated Hosp 2, Clin Lab, Wenzhou 325000, Zhejiang, Peoples R China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Gao, Shen-Meng,Yang, Junjun,Chen, Chiqi,et al. miR-15a/16-1 enhances retinoic acid-mediated differentiation of leukemic cells and is up-regulated by retinoic acid[J]. LEUKEMIA & LYMPHOMA,2011,52(12):2365-2371.
APA	Gao, Shen-Meng., Yang, Junjun., Chen, Chiqi., Zhang, Shenghui., Xing, Chong-Yun., ... & Jiang, Lei. (2011). miR-15a/16-1 enhances retinoic acid-mediated differentiation of leukemic cells and is up-regulated by retinoic acid. LEUKEMIA & LYMPHOMA, 52(12), 2365-2371.
MLA	Gao, Shen-Meng,et al."miR-15a/16-1 enhances retinoic acid-mediated differentiation of leukemic cells and is up-regulated by retinoic acid".LEUKEMIA & LYMPHOMA 52.12(2011):2365-2371.