Induction of apoptosis and autophagy in metastatic thyroid cancer cells by valproic acid (VPA)

科研成果详情

题名	Induction of apoptosis and autophagy in metastatic thyroid cancer cells by valproic acid (VPA)
作者	Xu, Yuan 1; Xu, Duo2; Zhu, Shao-Jun3; Ye, Bing3; Dong, Jian-Da3; Zhang, Yin-Long3; Zhang, Yi 3
发表日期	2015-12-31
发表期刊	INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Apoptosis cytotoxicity inhibited oxidative stress metastasis oxidative stress.
其他关键词	HISTONE DEACETYLASE INHIBITOR ; LEUKEMIA-CELLS ; BCR-ABL ; CARCINOMA ; DOXORUBICIN
摘要	The present study investigated the effect of valproic acid (VPA) on the inhibition of RET signaling and induction of apoptosis in human thyroid carcinoma cells. VPA inhibited the viability of ARO and WRO cells and also inhibited cyclin D1 and caused caspase-3 cleavage. VPA decreased the level of RET protein and blocked the activation of RET downstream targets including phosphorylated ERK, phosphorylated AKT, and p70S6K/pS6. VPA induced metabolic stress, activated AMP-activated protein kinase and increased autophagic flux. Pharmacological inhibition of autophagy (chloroquine) augmented VPA-inducible cytotoxicity, suggesting that autophagy was protective in VPA-treated cells. VPA has a wide spectrum of activity against human thyroid carcinoma cells, and its cytotoxicity can be augmented by inhibiting autophagy. Expression of VPA molecular targets in metastatic human thyroid carcinoma cells suggests that VPA has a potential to become a thyroid cancer therapeutic agent.
出版者	E-CENTURY PUBLISHING CORP
出版地	MADISON
ISSN	1936-2625
卷号	8 期号:7 页码:8291-8297
页数	7
WOS类目	Oncology ; Pathology
WOS研究方向	Oncology ; Pathology
WOS记录号	WOS:000361538900068
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	26339399
PMC记录号	PMC4555727
SCOPUSEID	2-s2.0-85013006897
通讯作者地址	[Xu, Yuan]Department of Surgical Oncology,The 2nd Affiliated Hospital,Wenzhou Medical University,109 West Xueyuan Road,Wenzhou, Zhejiang,325000,China
Scopus学科分类	Pathology and Forensic Medicine;Histology
引用统计	被引频次：14[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/13073
专题	第二临床医学院、附属第二医院、育英儿童医院附属第二医院附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_外科学_肿瘤外科
通讯作者	Xu, Yuan
作者单位	1.Department of Surgical Oncology,The 2nd Affiliated Hospital,Wenzhou Medical University,Wenzhou,325000,China; 2.Department of Operating Room,The 1st Affiliated Hospital,Wenzhou Medical University,Wenzhou,325000,China; 3.Department of Neck Surgery,The 2nd Affiliated Hospital,Wenzhou Medical University,Wenzhou,325000,China
第一作者单位	温州医科大学
通讯作者单位	温州医科大学
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Xu, Yuan,Xu, Duo,Zhu, Shao-Jun,et al. Induction of apoptosis and autophagy in metastatic thyroid cancer cells by valproic acid (VPA)[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,2015,8(7):8291-8297.
APA	Xu, Yuan., Xu, Duo., Zhu, Shao-Jun., Ye, Bing., Dong, Jian-Da., ... & Zhang, Yi. (2015). Induction of apoptosis and autophagy in metastatic thyroid cancer cells by valproic acid (VPA). INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 8(7), 8291-8297.
MLA	Xu, Yuan,et al."Induction of apoptosis and autophagy in metastatic thyroid cancer cells by valproic acid (VPA)".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 8.7(2015):8291-8297.