Thioredoxin-1 inhibitor PX-12 induces human acute myeloid leukemia cell apoptosis and enhances the sensitivity of cells to arsenic trioxide

科研成果详情

题名	Thioredoxin-1 inhibitor PX-12 induces human acute myeloid leukemia cell apoptosis and enhances the sensitivity of cells to arsenic trioxide
作者	Tan, Yingxia1; Bi, Laixi2; Zhang, Peili1; Wang, Fule1; Lin, Feiyan1; Ni, Wuhua3; Wu, Jianbo1; Jiang, Lei1
发表日期	2014-12-31
发表期刊	INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	PX-12 acute myeloid leukemia apoptosis arsenic trioxide arsenic trioxide.
其他关键词	ACUTE PROMYELOCYTIC LEUKEMIA ; 1-METHYLPROPYL 2-IMIDAZOLYL DISULFIDE ; MOLECULAR-MECHANISMS ; OXIDATIVE STRESS ; DOWN-REGULATION ; CANCER-CELLS ; EXPRESSION ; GROWTH ; DEATH ; TUMOR
摘要	Thioredoxin-1 (Trx-1), an important redox regulatory factor, plays a significant role in drug-induced apoptosis. Here we investigated the effects of the Trx-1 inhibitor 1-methylpropyl 2-imidazolyl disulfide (PX-12) on human acute myeloid leukemia cells (AML) and the sensitivity of cells to arsenic trioxide (As2O3, ATO). Treatment of cells with a different concentration of PX-12 for 48 h resulted in growth inhibition, the induction of apoptosis and increased the levels of activated caspase-3 expression in AML cell lines HL-60, NB4, U937 and primary AML cells in a dose-dependent manner. In addition, PX-12 enhanced the sensitivity of U937 cells to ATO. These results suggest the effects of Trx-1 inhibitor PX-12 to induce apoptosis in AML cells and therapeutic potential in AML by enhancing the sensitivity of cells to ATO.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81101823]; Medicine and Health Technology Program of Zhejiang Province [2013KYA129]; Wenzhou Science and Technology Bureau Program [Y20-120181]
出版者	E-CENTURY PUBLISHING CORP
出版地	MADISON
ISSN	1936-2625
卷号	7 期号:8 页码:4765-4773
页数	9
WOS类目	Oncology ; Pathology
WOS研究方向	Oncology ; Pathology
WOS记录号	WOS:000345120900019
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	25197347
PMC记录号	PMC4152037
SCOPUSEID	2-s2.0-84907919427
通讯作者地址	[Jiang, Lei]Laboratory of Internal Medicine, The First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang Province,325000,China
Scopus学科分类	Pathology and Forensic Medicine;Histology
引用统计	被引频次：19[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/1303
专题	附属第一医院_内科实验室附属第一医院附属第一医院_生殖医学中心
通讯作者	Jiang, Lei
作者单位	1.Laboratory of Internal Medicine, The First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang,325000,China; 2.Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang,325000,China; 3.Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang,325000,China
第一作者单位	附属第一医院_内科实验室
通讯作者单位	附属第一医院_内科实验室
第一作者的第一单位	附属第一医院_内科实验室
推荐引用方式 GB/T 7714	Tan, Yingxia,Bi, Laixi,Zhang, Peili,et al. Thioredoxin-1 inhibitor PX-12 induces human acute myeloid leukemia cell apoptosis and enhances the sensitivity of cells to arsenic trioxide[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,2014,7(8):4765-4773.
APA	Tan, Yingxia., Bi, Laixi., Zhang, Peili., Wang, Fule., Lin, Feiyan., ... & Jiang, Lei. (2014). Thioredoxin-1 inhibitor PX-12 induces human acute myeloid leukemia cell apoptosis and enhances the sensitivity of cells to arsenic trioxide. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 7(8), 4765-4773.
MLA	Tan, Yingxia,et al."Thioredoxin-1 inhibitor PX-12 induces human acute myeloid leukemia cell apoptosis and enhances the sensitivity of cells to arsenic trioxide".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 7.8(2014):4765-4773.