The ED95 of Nalbuphine in Outpatient-Induced Abortion Compared to Equivalent Sufentanil

doi:10.1111/bcpt.13022

科研成果详情

题名	The ED95 of Nalbuphine in Outpatient-Induced Abortion Compared to Equivalent Sufentanil
作者	Chen, Limei1; Zhou, Yamei2; Cai, Yaoyao1; Bao, Nana1; Xu, Xuzhong1; Shi, Beibei3
发表日期	2018-08
发表期刊	BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	SURGICAL ABORTION ; DOUBLE-BLIND ; TRIAL ; ANESTHESIA ; SEDATION ; PROPOFOL ; MORPHINE ; SAFETY ; PAIN
摘要	This prospective study evaluated the 95% effective dose (ED95) of nalbuphine in inhibiting body movement during outpatient-induced abortion and its clinical efficacy versus the equivalent of sufentanil. The study was divided into two parts. For the first part, voluntary first-trimester patients who needed induced abortions were recruited to measure the ED95 of nalbuphine in inhibiting body movement during induced abortion using the sequential method (the Dixon up-and-down method). In the second part, this was a double-blind, randomized study. Sixty cases of first-trimester patients were recruited and were randomly divided into two groups (n = 30), including group N (nalbuphine at the ED95 dose) and group S (sufentanil at an equivalent dose). Propofol was given to both groups as the sedative. The circulation, respiration and body movement of the two groups in surgery were observed. The amount of propofol, the awakening time, the time to leave the hospital and the analgesic effect were recorded. The ED95 of nalbuphine in inhibiting body movement during painless surgical abortion was 0.128 mg/kg (95% confidence intervals 0.098-0.483 mg/kg). Both nalbuphine and the equivalent dose of sufentanil provided a good intraoperative and post-operative analgesic effect in outpatient-induced abortion. However, the post-operative morbidity of dizziness for nalbuphine was less than for sufentanil (p < 0.05), and the awakening time and the time to leave the hospital were significantly shorter than those of sufentanil (p < 0.05). Nalbuphine at 0.128 mg/kg was used in outpatient-induced abortion as an intraoperative and post-operative analgesic and showed a better effect compared with sufentanil.
出版者	WILEY
出版地	HOBOKEN
ISSN	1742-7835
EISSN	1742-7843
卷号	123 期号:2 页码:202-206
DOI	10.1111/bcpt.13022
页数	5
WOS类目	Pharmacology & Pharmacy ; Toxicology
WOS研究方向	Pharmacology & Pharmacy ; Toxicology
WOS记录号	WOS:000438196400013
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	29626849
SCOPUSEID	2-s2.0-85047661694
通讯作者地址	[Xu, Xuzhong]Department of Anesthesiology,The First Affiliated Hospital,Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Toxicology;Pharmacology
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/13003
专题	附属第一医院其他_附属第五医院（丽水市中心医院）
通讯作者	Xu, Xuzhong
作者单位	1.Department of Anesthesiology,The First Affiliated Hospital,Wenzhou Medical University,Wenzhou,China; 2.Department of Anesthesiology,Lishui Central Hospital,The Fifth Affiliated Hospital,Wenzhou Medical University,Lishui,China; 3.Department of gynecology,The First Affiliated Hospital,Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Chen, Limei,Zhou, Yamei,Cai, Yaoyao,et al. The ED95 of Nalbuphine in Outpatient-Induced Abortion Compared to Equivalent Sufentanil[J]. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY,2018,123(2):202-206.
APA	Chen, Limei, Zhou, Yamei, Cai, Yaoyao, Bao, Nana, Xu, Xuzhong, & Shi, Beibei. (2018). The ED95 of Nalbuphine in Outpatient-Induced Abortion Compared to Equivalent Sufentanil. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 123(2), 202-206.
MLA	Chen, Limei,et al."The ED95 of Nalbuphine in Outpatient-Induced Abortion Compared to Equivalent Sufentanil".BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 123.2(2018):202-206.