Molecular characterization of mitochondrial transferRNA(Gln) and transferRNA(Met) A4401G mutations in a Chinese family with hypertension

doi:10.3892/mmr.2017.6216

科研成果详情

题名	Molecular characterization of mitochondrial transferRNA(Gln) and transferRNA(Met) A4401G mutations in a Chinese family with hypertension
作者	Yu, Shuai-Shuai1; Du, Ji-Mei1; Tang, Zhi-De 1; He, Zhi-Feng2
发表日期	2017-04
发表期刊	MOLECULAR MEDICINE REPORTS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	hypertension G5821A A4401G transfer RNA mutation Chinese family
其他关键词	MATERNALLY INHERITED HYPERTENSION ; COMPLETE NUCLEOTIDE-SEQUENCE ; CARDIOMYOPATHY ; GENE
摘要	Mutations in mitochondrial (mt) transfer (t) RNA (mt-tRNA) have been reported to serve important roles in hypertension. To determine the underlying molecular mechanisms of mt-tRNA mutations in hypertension, the present study screened for mt-tRNA mutations in a Chinese family with a high incidence of essential hypertension. Sequence analysis of the mt-tRNA genes in this family revealed the presence of an A4401G mutation in the glycine-and methionine-tRNA genes, and a G5821A mutation in the cysteine-tRNA ( tRNACys) gene. The G5821A mutation was located at a position conserved in various species, and disrupted G6-C67 base-pairing. It was hypothesized that the G5821A mutation may decrease the baseline expression levels of tRNACys, and consequently result in failure of tRNA metabolism. The A4401G mutation was reported to cause the mitochondrial dysfunction responsible for hypertension. Thus, the combination of G5821A and A4401G mutations may contribute to the high incidence of hypertension in this family. Mt-tRNA mutations may serve as potential biomarkers for hypertension.
出版者	SPANDIDOS PUBL LTD
出版地	ATHENS
ISSN	1791-2997
EISSN	1791-3004
卷号	15 期号:4 页码:1832-1836
DOI	10.3892/mmr.2017.6216
页数	5
WOS类目	Oncology ; Medicine, Research & Experimental
WOS研究方向	Oncology ; Research & Experimental Medicine
WOS记录号	WOS:000397203200051
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	28259969
SCOPUSEID	2-s2.0-85015679766
通讯作者地址	[He, Zhi-Feng]Department of Cardiothoracic Surgery,First Affiliated Hospital,Wenzhou Medical University,2 Fu Xue Xiang Road,Wenzhou, Zhejiang,325035,China
Scopus学科分类	Biochemistry;Molecular Medicine;Molecular Biology;Genetics;Oncology;Cancer Research
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/12858
专题	检验医学院（生命科学学院、生物学实验教学中心）附属第一医院基础医学院（机能实验教学中心）_生物科学系
通讯作者	He, Zhi-Feng
作者单位	1.Department of Biology,School of Laboratory Medicine and Life Science,Wenzhou Medical University,China; 2.Department of Cardiothoracic Surgery,First Affiliated Hospital,Wenzhou Medical University,2 Fu Xue Xiang Road,Wenzhou, Zhejiang,325035,China
第一作者单位	检验医学院（生命科学学院、生物学实验教学中心）
通讯作者单位	附属第一医院
第一作者的第一单位	检验医学院（生命科学学院、生物学实验教学中心）
推荐引用方式 GB/T 7714	Yu, Shuai-Shuai,Du, Ji-Mei,Tang, Zhi-De,et al. Molecular characterization of mitochondrial transferRNA(Gln) and transferRNA(Met) A4401G mutations in a Chinese family with hypertension[J]. MOLECULAR MEDICINE REPORTS,2017,15(4):1832-1836.
APA	Yu, Shuai-Shuai, Du, Ji-Mei, Tang, Zhi-De, & He, Zhi-Feng. (2017). Molecular characterization of mitochondrial transferRNA(Gln) and transferRNA(Met) A4401G mutations in a Chinese family with hypertension. MOLECULAR MEDICINE REPORTS, 15(4), 1832-1836.
MLA	Yu, Shuai-Shuai,et al."Molecular characterization of mitochondrial transferRNA(Gln) and transferRNA(Met) A4401G mutations in a Chinese family with hypertension".MOLECULAR MEDICINE REPORTS 15.4(2017):1832-1836.