Therapeutic effects of Houttuynia eye drops combined with olopatadine hydrochloride eye drops on vernal keratoconjunctivitis

doi:10.3892/etm.2018.7079

科研成果详情

题名	Therapeutic effects of Houttuynia eye drops combined with olopatadine hydrochloride eye drops on vernal keratoconjunctivitis
作者	Xu, Xuegu; Cai, Yonghao
发表日期	2019-02
发表期刊	EXPERIMENTAL AND THERAPEUTIC MEDICINE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	vernal keratoconjunctivitis houttuynia eye drops olopatadine hydrochloride eye drops efficacy
其他关键词	CONFOCAL MICROSCOPY ; PATHOGENESIS ; TACROLIMUS ; EFFICACY ; SAFETY
摘要	Therapeutic effects and safety of houttuynia eye drops combined with olopatadine hydrochloride eye drops on vernal keratoconjunctivitis (VK) were evaluated. A total of 926 patients with VK were collected in the Eye Hospital of Wenzhou Medical University from July 2011 to January 2017. Patients were divided into group A, B and C according to the use of different eye drops. Group A included 276 patients who were treated with houttuynia eye drops; group B included 305 patients who were treated with olopatadine hydrochloride eye drops; group C included 345 patients who were treated with houttuynia eye drops and olopatadine hydrochloride eye drops. Treatment was performed for 14 days. Eye symptoms before and after treatment, and at 1 h, 7 days and 14 days after drug administration were compared among groups to evaluate the therapeutic effect. At 1 h after drug administration, highest excellent rate was observed in group C, followed by group A, and good outcome rate was significantly higher in group C than in the other two groups (P<0.05), and effective rate was also significantly higher in group C than in the other two groups (P<0.05). At 7 days after treatment, excellent rate was significantly higher in group C than in the other two groups (P<0.05), and effective rate was higher in group C than in group B (P<0.05). At 14 days after treatment, excellent rate was significantly higher in group C than in the other two groups (P<0.05), while lowest good outcome rate and ineffective rate were found in group C, and no significant differences were found between group A and B (P>0.05). Houttuynia ophthalmic solution and olopatadine hydrochloride eye drops can both achieve good effect in the treatment of VK, and combined use of them can increase the efficacy and shorten treatment period. So, the combined treatment should be popularized.
资助项目	Wenzhou City Science and Technology Project (Wenzhou, China) [Y20160533]
出版者	SPANDIDOS PUBL LTD
出版地	ATHENS
ISSN	1792-0981
EISSN	1792-1015
卷号	17 期号:2 页码:1224-1227
DOI	10.3892/etm.2018.7079
页数	4
WOS类目	Medicine, Research & Experimental
WOS研究方向	Research & Experimental Medicine
WOS记录号	WOS:000455641300034
收录类别	SCIE ; PUBMED
URL	查看原文
PubMed ID	30679995
PMC记录号	PMC6327635
通讯作者地址	[Xu, Xuegu]Wenzhou Med Univ, Eye Hosp, Dept Pharm, 270 Xueyuanxi Rd, Wenzhou 325003, Zhejiang, Peoples R China.
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/12819
专题	眼视光学院（生物医学工程学院）、附属眼视光医院_药剂科
通讯作者	Xu, Xuegu
作者单位	Wenzhou Med Univ, Eye Hosp, Dept Pharm, 270 Xueyuanxi Rd, Wenzhou 325003, Zhejiang, Peoples R China
第一作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院_药剂科
通讯作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院_药剂科
第一作者的第一单位	眼视光学院（生物医学工程学院）、附属眼视光医院_药剂科
推荐引用方式 GB/T 7714	Xu, Xuegu,Cai, Yonghao. Therapeutic effects of Houttuynia eye drops combined with olopatadine hydrochloride eye drops on vernal keratoconjunctivitis[J]. EXPERIMENTAL AND THERAPEUTIC MEDICINE,2019,17(2):1224-1227.
APA	Xu, Xuegu, & Cai, Yonghao. (2019). Therapeutic effects of Houttuynia eye drops combined with olopatadine hydrochloride eye drops on vernal keratoconjunctivitis. EXPERIMENTAL AND THERAPEUTIC MEDICINE, 17(2), 1224-1227.
MLA	Xu, Xuegu,et al."Therapeutic effects of Houttuynia eye drops combined with olopatadine hydrochloride eye drops on vernal keratoconjunctivitis".EXPERIMENTAL AND THERAPEUTIC MEDICINE 17.2(2019):1224-1227.