Influence of icariin on inflammation, apoptosis, invasion, and tumor immunity in cervical cancer by reducing the TLR4/MyD88/NF-kappa B and Wnt/beta-catenin pathways

doi:10.1186/s12935-021-01910-2

科研成果详情

题名	Influence of icariin on inflammation, apoptosis, invasion, and tumor immunity in cervical cancer by reducing the TLR4/MyD88/NF-kappa B and Wnt/beta-catenin pathways
作者	Li, Chunyang2; Yang, Shuangqing 1; Ma, Huaqing1; Ruan, Mengjia1; Fang, Luyan1; Cheng, Jing1
发表日期	2021-04-13
发表期刊	CANCER CELL INTERNATIONAL 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Icariin Cervical cancer Inflammation Tumor immunity Microbiota
其他关键词	TRADITIONAL CHINESE MEDICINE ; COLORECTAL-CANCER ; HELA-CELLS ; EXPRESSION ; POLYSACCHARIDES ; MICROBIOME ; CARCINOMA ; GROWTH
摘要	BackgroundCervical cancer is a type of the most common gynecology tumor in women of the whole world. Accumulating data have shown that icariin (ICA), a natural compound, has anti-cancer activity in different cancers, including cervical cancer. The study aimed to reveal the antitumor effects and the possible underlying mechanism of ICA in U14 tumor-bearing mice and SiHa cells.MethodsThe antitumor effects of ICA were investigated in vivo and in vitro. The expression of TLR4/MyD88/NF-kappa B and Wnt/beta -catenin signaling pathways were evaluated.ResultsWe found that ICA significantly suppressed tumor tissue growth and SiHa cells viability in a dose-dependent manner. Also, ICA enhanced the anti-tumor humoral immunity in vivo. Moreover, ICA significantly improved the composition of the microbiota in mice models. Additionally, the results clarified that ICA significantly inhibited the migration, invasion capacity, and expression levels of TGF-beta 1, TNF-alpha, IL-6, IL-17A, IL-10 in SiHa cells. Meanwhile, ICA was revealed to promote the apoptosis of cervical cancer cells by down-regulating Ki67, survivin, Bcl-2, c-Myc, and up-regulating P16, P53, Bax levels in vivo and in vitro. For the part of mechanism exploration, we showed that ICA inhibits the inflammation, proliferation, migration, and invasion, as well as promotes apoptosis and immunity in cervical cancer through impairment of TLR4/MyD88/NF-kappa B and Wnt/beta -catenin pathways.ConclusionsTaken together, ICA could be a potential supplementary agent for cervical cancer treatment.
出版者	BMC
出版地	LONDON
ISSN	1475-2867
EISSN	1475-2867
卷号	21 期号:1 页码:206
DOI	10.1186/s12935-021-01910-2
页数	14
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000640255800003
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	33849528
PMC记录号	PMC8045342
SCOPUSEID	2-s2.0-85104297939
通讯作者地址	[Cheng, Jing]Department of Gynecology and Obstetrics,Reproductive Center,the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Oncology;Genetics;Cancer Research
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/12584
专题	第二临床医学院，附属第二医院、育英儿童医院基础医学院（机能实验教学中心）_生物科学系_生物化学与分子生物学
通讯作者	Cheng, Jing
作者单位	1.Department of Gynecology and Obstetrics,Reproductive Center,the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,China; 2.Department of Biochemistry,School of Basic Sciences,Wenzhou Medical University,Wenzhou,China
第一作者单位	基础医学院（机能实验教学中心）_生物科学系_生物化学与分子生物学
通讯作者单位	第二临床医学院，附属第二医院、育英儿童医院
第一作者的第一单位	基础医学院（机能实验教学中心）_生物科学系_生物化学与分子生物学
推荐引用方式 GB/T 7714	Li, Chunyang,Yang, Shuangqing,Ma, Huaqing,et al. Influence of icariin on inflammation, apoptosis, invasion, and tumor immunity in cervical cancer by reducing the TLR4/MyD88/NF-kappa B and Wnt/beta-catenin pathways[J]. CANCER CELL INTERNATIONAL,2021,21(1):206.
APA	Li, Chunyang, Yang, Shuangqing, Ma, Huaqing, Ruan, Mengjia, Fang, Luyan, & Cheng, Jing. (2021). Influence of icariin on inflammation, apoptosis, invasion, and tumor immunity in cervical cancer by reducing the TLR4/MyD88/NF-kappa B and Wnt/beta-catenin pathways. CANCER CELL INTERNATIONAL, 21(1), 206.
MLA	Li, Chunyang,et al."Influence of icariin on inflammation, apoptosis, invasion, and tumor immunity in cervical cancer by reducing the TLR4/MyD88/NF-kappa B and Wnt/beta-catenin pathways".CANCER CELL INTERNATIONAL 21.1(2021):206.