Association between polycystic ovary syndrome and the risk of pregnancy complications A PRISMA-compliant systematic review and meta-analysis

doi:10.1097/MD.0000000000004863

科研成果详情

题名	Association between polycystic ovary syndrome and the risk of pregnancy complications A PRISMA-compliant systematic review and meta-analysis
作者	Yu, Hai-Feng 1; Chen, Hong-Su 2; Rao, Da-Pang 1; Gong, Jian3
发表日期	2016-12
发表期刊	MEDICINE 影响因子和分区
语种	英语
原始文献类型	Review
关键词	meta-analysis polycystic ovary syndrome pregnancy complications risk systematic review
其他关键词	GESTATIONAL DIABETES-MELLITUS ; IMPAIRED GLUCOSE-TOLERANCE ; SYNDROME PCOS ; METABOLIC PARAMETERS ; WOMEN ; OUTCOMES ; PREVALENCE ; BIAS
摘要	Background: Polycystic ovary syndrome (PCOS) is inconsistently associated with increased risk of adverse pregnancy outcomes. The purpose of this meta-analysis was to summarize the evidence regarding the strength of the association between pregnancy in women with PCOS and pregnancy complications. Methods: We systematically searched PubMed, EmBase, and the Cochrane Library to identify observational studies up to January 2016. The primary focus was pregnancy outcomes, including gestational diabetes mellitus (GDM), preeclampsia, pregnancyinduced hypertension (PIH), preterm delivery, cesarean delivery, oligohydramnios, and polyhydramnios. Effect estimates were pooled using the random-effects model. The analysis was further stratified by factors that could affect these associations. Results: We included 40 observational studies that reported data on a total of 17,816 pregnancies with PCOS and 123,756 pregnancies without PCOS. Overall, PCOS in pregnancy was associated with greater risk of GDM, preeclampsia, PIH, preterm delivery, cesarean delivery, miscarriage, hypoglycemia, and perinatal death. However, PCOS in pregnancy had little or no effect on oligohydramnios, polyhydramnios, large-for-gestational age (LGA), small-for-gestational-age (SGA), fetal growth restriction (FGR), preterm premature membrane rupture, fasting blood glucose (FBG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglyceride, total cholesterol, congenital malformation, macrosomia, and respiratory distress syndrome. Subgroup analysis suggested that these associations might be influenced by study design and pre-BMI. Conclusion: PCOS in pregnancy is associated with a significantly increased risk of adverse pregnancy, fetal, and neonatal outcomes.
出版者	LIPPINCOTT WILLIAMS & WILKINS
出版地	PHILADELPHIA
ISSN	0025-7974
EISSN	1536-5964
卷号	95 期号:51 页码:e4863.
DOI	10.1097/MD.0000000000004863
页数	12
WOS类目	Medicine, General & Internal
WOS研究方向	General & Internal Medicine
WOS记录号	WOS:000391623300002
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	28002314
PMC记录号	PMC5181798
SCOPUSEID	2-s2.0-85007359570
通讯作者地址	[Gong, Jian]Medical Laboratory Center,Second Affiliated Hospital,Wenzhou Medical University,Wenzhou,325027,China
Scopus学科分类	Medicine (all)
引用统计	被引频次：117[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/12506
专题	附属第二医院
通讯作者	Gong, Jian
作者单位	1.Department of Urosurgery,United States; 2.Department of Cardiothoracic Surgery,United States; 3.Medical Laboratory Center,Second Affiliated Hospital,Wenzhou Medical University,Wenzhou,325027,China
通讯作者单位	附属第二医院
推荐引用方式 GB/T 7714	Yu, Hai-Feng,Chen, Hong-Su,Rao, Da-Pang,et al. Association between polycystic ovary syndrome and the risk of pregnancy complications A PRISMA-compliant systematic review and meta-analysis[J]. MEDICINE,2016,95(51):e4863..
APA	Yu, Hai-Feng, Chen, Hong-Su, Rao, Da-Pang, & Gong, Jian. (2016). Association between polycystic ovary syndrome and the risk of pregnancy complications A PRISMA-compliant systematic review and meta-analysis. MEDICINE, 95(51), e4863..
MLA	Yu, Hai-Feng,et al."Association between polycystic ovary syndrome and the risk of pregnancy complications A PRISMA-compliant systematic review and meta-analysis".MEDICINE 95.51(2016):e4863..