Downregulation of lncRNA TUBA4B is Associated with Poor Prognosis for Epithelial Ovarian Cancer

doi:10.1007/s12253-017-0258-7

科研成果详情

题名	Downregulation of lncRNA TUBA4B is Associated with Poor Prognosis for Epithelial Ovarian Cancer
作者	Zhu, Fang-Fang1; Zheng, Fei-Yun1; Wang, Hai-Ou2; Zheng, Jing-Jie1; Zhang, Qian1
发表日期	2018-04
发表期刊	PATHOLOGY & ONCOLOGY RESEARCH 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Ovarian cancer lncRNA Overall survival Proliferation
其他关键词	CELL-PROLIFERATION ; PROMOTES ; RNA
摘要	A host of studies have revealed that long non-coding RNAs (lncRNAs) are critically involved in the development and progression of epithelial ovarian cancer. LncRNA TUBA4B is recently identified to be a critical mediator in non-small cell lung cancer. However, the clinical roles and biological functions of lncRNA TUBA4B in epithelial ovarian cancer have yet to be fully clarified. The present study was conducted to explore the expression of lncRNA TUBA4B in human epithelial ovarian cancer tissues and potential roles of lncRNA TUBA4B in ovarian cancer cells. The matched epithelial ovarian cancer specimens and adjacent normal tissues were employed to detect the expression of lncRNA TUBA4B. The prognostic value of lncRNA TUBA4B for tumor progression and survival rate was investigated. The effects of lncRNA TUBA4B on ovarian cancer cell proliferation and migration were also explored. The expression of lncRNA TUBA4B was significantly decreased in epithelial ovarian cancer tissue specimens. The low lncRNA TUBA4B level was closely related with pathological grade, FIGO stage and lymph node metastases, and serum CA125 level. Enforced expression of lncRNA TUBA4B obviously reduced the proliferation of SKOV3 cells, and attenuated the activation of ERK and Akt signaling pathways. Our data demonstrate for the first time that lower lncRNA TUBA4B may be a novel independent prognostic biomarker for overall survival of epithelial ovarian cancer. Overexpression of lncRNA TUBA4B inhibits the proliferation of ovarian cancer cells. LncRNA TUBA4B may be an important target for therapeutic intervention in ovarian cancer.
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
ISSN	1219-4956
EISSN	1532-2807
卷号	24 期号:2 页码:419-425
DOI	10.1007/s12253-017-0258-7
页数	7
WOS类目	Oncology ; Pathology
WOS研究方向	Oncology ; Pathology
WOS记录号	WOS:000427432400028
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	28578489
SCOPUSEID	2-s2.0-85020075012
通讯作者地址	[Zhang, Qian]Department of Gynaecology,the First Affiliated Hospital of Wenzhou Medical University,1 Fuxue Lane, Lucheng District, Wenzhou,Zhejiang,325000,China
Scopus学科分类	Pathology and Forensic Medicine;Oncology;Cancer Research
引用统计	被引频次：29[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/1248
专题	附属第一医院_妇科
通讯作者	Zhang, Qian
作者单位	1.Department of Gynaecology,the First Affiliated Hospital of Wenzhou Medical University,1 Fuxue Lane, Lucheng District, Wenzhou,Zhejiang,325000,China; 2.Department of Obstetrics and Gynecolog,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zhu, Fang-Fang,Zheng, Fei-Yun,Wang, Hai-Ou,et al. Downregulation of lncRNA TUBA4B is Associated with Poor Prognosis for Epithelial Ovarian Cancer[J]. PATHOLOGY & ONCOLOGY RESEARCH,2018,24(2):419-425.
APA	Zhu, Fang-Fang, Zheng, Fei-Yun, Wang, Hai-Ou, Zheng, Jing-Jie, & Zhang, Qian. (2018). Downregulation of lncRNA TUBA4B is Associated with Poor Prognosis for Epithelial Ovarian Cancer. PATHOLOGY & ONCOLOGY RESEARCH, 24(2), 419-425.
MLA	Zhu, Fang-Fang,et al."Downregulation of lncRNA TUBA4B is Associated with Poor Prognosis for Epithelial Ovarian Cancer".PATHOLOGY & ONCOLOGY RESEARCH 24.2(2018):419-425.