Peripheral Arterial Disease in Type 2 Diabetes Is Associated with an Increase in Fibrinogen Levels

doi:10.1155/2018/3709534

科研成果详情

题名	Peripheral Arterial Disease in Type 2 Diabetes Is Associated with an Increase in Fibrinogen Levels
作者	Chen, Qin-Fen1; Cao, Dan 2; Ye, Ting-Ting3; Deng, Hui-Hui3; Zhu, Hong3
发表日期	2018-12-31
发表期刊	INTERNATIONAL JOURNAL OF ENDOCRINOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	CARDIOVASCULAR RISK-FACTORS ; DIGITAL-SUBTRACTION-ANGIOGRAPHY ; C-REACTIVE PROTEIN ; LOWER-EXTREMITY ; METABOLIC SYNDROME ; TASK-FORCE ; ATHEROSCLEROSIS ; GUIDELINES ; SOCIETY ; MARKERS
摘要	Background. The present study is undertaken to investigate the fibrinogen levels in type 2 diabetes mellitus (T2DM) and its relation to peripheral artery disease (PAD) based on a more accurate and applied noninvasive measurements of duplex ultrasonography. Methods. We performed a cross-sectional study including 1096 T2DM patients (474 males and 622 females). The odds ratios (ORs) and 95% confidence intervals (CIs) were presented to show the association between PAD and fibrinogen in the subjects divided by fibrinogen levels quarterly. Furthermore, the univariate and multiple logistic analyses were performed to explore the correlation between PAD and fibrinogen levels, individual components in the cross-sectional study. Results. Finally, 887 (80.9%) T2DM patients meet the diagnostic criteria of PAD and these patients had considerably higher serum fibrinogen concentration than non-PAD group (P < 0 001). Multiple logistic analyses revealed that higher fibrinogen quartiles were positively related with the development of PAD in the adjusted model. After adjusting for known confounding parameters, the ORs for PAD were 1.993 (95% CI: 1.322-3.005, P < 0 001), 2.469 (95% CI: 1.591-3.831, P < 0 001), and 2.942 (95% CI, 1.838-4.711, P < 0 001) for Q2, Q3, and Q4, respectively (all P values <0.05). Conclusions. Our results suggest that serum fibrinogen concentration can be considered as an independent risk factor for PAD in T2DM patients.
出版者	HINDAWI LTD
出版地	LONDON
ISSN	1687-8337
EISSN	1687-8345
卷号	2018 页码:3709534
DOI	10.1155/2018/3709534
页数	8
WOS类目	Endocrinology & Metabolism
WOS研究方向	Endocrinology & Metabolism
WOS记录号	WOS:000450771400001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	30532778
PMC记录号	PMC6250013
SCOPUSEID	2-s2.0-85057254691
通讯作者地址	[Zhu, Hong]Department of Endocrinology and Metabolism,First Affiliated Hospital,Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Endocrinology, Diabetes and Metabolism;Endocrinology;Endocrine and Autonomic Systems
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/12288
专题	第一临床医学院（信息与工程学院）、附属第一医院_医疗保健中心第一临床医学院（信息与工程学院）、附属第一医院附属第一医院_内分泌科
通讯作者	Zhu, Hong
作者单位	1.Medical and Health Care Center,First Affiliated Hospital,Wenzhou Medical University,Wenzhou,325000,China; 2.School of the First Clinical Medical Sciences,Wenzhou Medical University,Wenzhou,325000,China; 3.Department of Endocrinology and Metabolism,First Affiliated Hospital,Wenzhou Medical University,Wenzhou,325000,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Chen, Qin-Fen,Cao, Dan,Ye, Ting-Ting,et al. Peripheral Arterial Disease in Type 2 Diabetes Is Associated with an Increase in Fibrinogen Levels[J]. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY,2018,2018:3709534.
APA	Chen, Qin-Fen, Cao, Dan, Ye, Ting-Ting, Deng, Hui-Hui, & Zhu, Hong. (2018). Peripheral Arterial Disease in Type 2 Diabetes Is Associated with an Increase in Fibrinogen Levels. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, 2018, 3709534.
MLA	Chen, Qin-Fen,et al."Peripheral Arterial Disease in Type 2 Diabetes Is Associated with an Increase in Fibrinogen Levels".INTERNATIONAL JOURNAL OF ENDOCRINOLOGY 2018(2018):3709534.