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Title颅脑损伤后脑组织rstn基因表达变化
Creator
Date Issued2009-12-03
Source Publication2009年浙江省急诊医学学术年会论文汇编   Impact Factor & Quartile
language中文
Original Document Type中国会议
Keyword颅脑损伤 rstn基因 时程变化 血糖浓度
Abstract目的探讨颅脑损伤大鼠脑组织rstn基因表达的时程变化。方法选择SD大鼠,随机分成正常对照组,假手术组,轻度、中度和重度损伤组。应用液压冲击法制作大鼠颅脑损伤模型,并检测各组大鼠的伤后3h、6h、24h、72 h、1w、2 w、4w脑组织标本,应用RT-PCR方法检查rstn基因表达变化,同时监测损伤中度组大鼠外周血糖浓度变化,观察其与脑组织rstn基因表达关系。结果中、重度损伤组大鼠的rstn基因表达上升时间较早,早于轻度损伤组,伤情越严重rstn基因表达上升时间越靠前,且其表达的量也越大。对于损伤不同区域观察的rstn基因表达变化发现以海马区域的rstn基因表达升高最明显,以丘脑区域rstn基因表达升高最不明显,并以同侧变化最为明显。脑组织rstn基因表达变化与外周血糖浓度呈现线性正相关。结论颅脑损伤后rstn基因表达发生明显变化,重度损伤组rstn基因升高最早且表达量最多,其中主要以同侧海马区域表达最为明显,中度损伤组脑组织rstn基因表达变化与外周血糖浓度线性正相关。
Publication Place浙江省科学技术协会
Pages1
Indexed By万方 ; CNKI
URL查看原文
category numberR651.15
Conference Name第七届全国创伤学术会议暨2009海峡两岸创伤医学论坛
Conference Place中国浙江杭州
Document TypeConference paper
Identifierhttps://kms.wmu.edu.cn/handle/3ETUA0LF/122715
CollectionWenzhou Medical University The Affiliated Second Hospital
Affiliation
温州医学院附属第二医院急诊科
First Author AffilicationWenzhou Medical University The Affiliated Second Hospital
First Signature AffilicationWenzhou Medical University The Affiliated Second Hospital
Recommended Citation
GB/T 7714
陈大庆,朱烈烈,李永领,等. 颅脑损伤后脑组织rstn基因表达变化[C]. 浙江省科学技术协会,2009:1.

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