The Protective Effect of Basic Fibroblast Growth Factor on Diabetic Nephropathy Through Remodeling Metabolic Phenotype and Suppressing Oxidative Stress in Mice

doi:10.3389/fphar.2020.00066

科研成果详情

题名	The Protective Effect of Basic Fibroblast Growth Factor on Diabetic Nephropathy Through Remodeling Metabolic Phenotype and Suppressing Oxidative Stress in Mice
作者	Wei, Tingting 1,2; Shu, Qi 1; Ning, Jie 1; Wang, Shuaijie 1; Li, Chen 1; Zhao, Liangcai1; Zheng, Hong1; Gao, Hongchang1
发表日期	2020-02-21
发表期刊	FRONTIERS IN PHARMACOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	bFGF diabetes metabolomics nephropathy taurine oxidative stress
其他关键词	TRIMETHYLAMINE-N-OXIDE ; KIDNEY ; RATS ; DAMAGE ; MYOINOSITOL ; DYSFUNCTION ; PROGRESSION ; MECHANISMS ; INJURY
摘要	Diabetic nephropathy is a common complication in diabetes, but still lack of effective therapeutic strategies. This study aimed to investigate the therapeutic effect of basic fibroblast growth factor (bFGF) in db/db mice with diabetic nephropathy and explore its possible metabolic mechanisms using a nuclear magnetic resonance-based metabolomic approach. We found that bFGF treatment significantly alleviate urinary albumin to creatinine ratio and renal fibrosis in db/db mice, suggesting a potential renal protective effect. Metabolomics results reveal that bFGF remodeled metabolic phenotypes of the kidney and urine in db/db mice, mainly involving energy metabolism, methylamine metabolism, osmoregulation, and oxidative stress. Furthermore, the results show that bFGF-induced reductions of oxidative stress and apoptosis in db/db mice might be mediated by NOX-ROS-Nrf2 signaling. Therefore, our study suggests that the protective effect of bFGF on diabetic nephropathy could be mediated by remodeling metabolic phenotype and suppressing oxidative stress.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81600653, 21605115, 21974096]
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
ISSN	1663-9812
卷号	11 页码:66
DOI	10.3389/fphar.2020.00066
页数	12
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:000525235600001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	32153399
PMC记录号	PMC7046551
SCOPUSEID	2-s2.0-85081257954
通讯作者地址	[Zheng, Hong]School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Pharmacology;Pharmacology (medical)
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/1215
专题	药学院（分析测试中心）实验动物中心
通讯作者	Zheng, Hong
作者单位	1.School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,China; 2.Laboratory Animal Centre,Wenzhou Medical University,Wenzhou,China
第一作者单位	药学院（分析测试中心）; 温州医科大学
通讯作者单位	药学院（分析测试中心）
第一作者的第一单位	药学院（分析测试中心）
推荐引用方式 GB/T 7714	Wei, Tingting,Shu, Qi,Ning, Jie,et al. The Protective Effect of Basic Fibroblast Growth Factor on Diabetic Nephropathy Through Remodeling Metabolic Phenotype and Suppressing Oxidative Stress in Mice[J]. FRONTIERS IN PHARMACOLOGY,2020,11:66.
APA	Wei, Tingting., Shu, Qi., Ning, Jie., Wang, Shuaijie., Li, Chen., ... & Gao, Hongchang. (2020). The Protective Effect of Basic Fibroblast Growth Factor on Diabetic Nephropathy Through Remodeling Metabolic Phenotype and Suppressing Oxidative Stress in Mice. FRONTIERS IN PHARMACOLOGY, 11, 66.
MLA	Wei, Tingting,et al."The Protective Effect of Basic Fibroblast Growth Factor on Diabetic Nephropathy Through Remodeling Metabolic Phenotype and Suppressing Oxidative Stress in Mice".FRONTIERS IN PHARMACOLOGY 11(2020):66.