科研成果详情

题名Development and Evaluation of Nomograms to Predict the Cancer-Specific Mortality and Overall Mortality of Patients with Hepatocellular Carcinoma
作者
发表日期2021-03-30
发表期刊BIOMED RESEARCH INTERNATIONAL   影响因子和分区
语种英语
原始文献类型Article
摘要Hepatocellular carcinoma (HCC) is the most common type among primary liver cancers (PLC). With its poor prognosis and survival rate, it is necessary for HCC patients to have a long-term follow-up. We believe that there are currently no relevant reports or literature about nomograms for predicting the cancer-specific mortality of HCC patients. Therefore, the primary goal of this study was to develop and evaluate nomograms to predict cancer-specific mortality and overall mortality. Data of 45,158 cases of HCC patients were collected from the Surveillance, Epidemiology, and End Results (SEER) program database between 2004 and 2013, which were then utilized to develop the nomograms. Finally, the performance of the nomograms was evaluated by the concordance index (C-index) and the area under the time-dependent receiver operating characteristic (ROC) curve (td-AUC). The categories selected to develop a nomogram for predicting cancer-specific mortality included marriage, insurance, radiotherapy, surgery, distant metastasis, lymphatic metastasis, tumor size, grade, sex, and the American Joint Committee on Cancer (AJCC) stage; while the marriage, radiotherapy, surgery, AJCC stage, grade, race, sex, and age were selected to develop a nomogram for predicting overall mortality. The C-indices for predicted 1-, 3-, and 5-year cancer-specific mortality were 0.792, 0.776, and 0.774; the AUC values for 1-, 3-, and 5-year cancer-specific mortality were 0.830, 0.830, and 0.830. The C-indices for predicted 1-, 3-, and 5-year overall mortality were 0.770, 0.755, and 0.752; AUC values for predicted 1-, 3-, and 5-year overall mortality were 0.820, 0.820, and 0.830. The results showed that the nomograms possessed good agreement compared with the observed outcomes. It could provide clinicians with a personalized predicted risk of death information to evaluate the potential changes of the disease-specific condition so that clinicians can adjust therapy options when combined with the actual condition of the patient, which is beneficial to patients.
资助项目Youth Foundation of National Natural Science Foundation of China [81700568]; Zhejiang Medical and Health Science and Technology Plan Project [2019RC210]; Natural Science Foundation of Zhejiang ProvinceNatural Science Foundation of Zhejiang Province [LY17H160057]
出版者HINDAWI LTD
出版地LONDON
ISSN2314-6133
EISSN2314-6141
卷号2021页码:1658403
DOI10.1155/2021/1658403
页数12
WOS类目Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
WOS研究方向Biotechnology & Applied Microbiology ; Research & Experimental Medicine
WOS记录号WOS:000640307900009
收录类别SCIE ; PUBMED ; SCOPUS
URL查看原文
PubMed ID33860031
PMC记录号PMC8024067
SCOPUSEID2-s2.0-85104459621
通讯作者地址[Chen, Lei]Department of Surgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang Province,China ; [Kong, Hongru]Department of Surgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang Province,China
Scopus学科分类Immunology and Microbiology (all);Biochemistry, Genetics and Molecular Biology (all)
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/12038
专题第一临床医学院(信息与工程学院)、附属第一医院
附属第一医院_骨科
第一临床医学院(信息与工程学院)、附属第一医院_浙江省胰脏肝脏危重性疾病重点实验室
通讯作者Chen, Lei; Kong, Hongru
作者单位
1.Department of Surgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang Province,China;
2.Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province,Zhejiang Provincial Top Key Discipline in Surgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang Province,China;
3.Department of Orthopaedics,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang Province,China
第一作者单位附属第一医院;  第一临床医学院(信息与工程学院)、附属第一医院
通讯作者单位附属第一医院;  第一临床医学院(信息与工程学院)、附属第一医院
第一作者的第一单位附属第一医院
推荐引用方式
GB/T 7714
Ni, Xiaofeng,Li, Ding,Dai, Shengjie,et al. Development and Evaluation of Nomograms to Predict the Cancer-Specific Mortality and Overall Mortality of Patients with Hepatocellular Carcinoma[J]. BIOMED RESEARCH INTERNATIONAL,2021,2021:1658403.
APA Ni, Xiaofeng., Li, Ding., Dai, Shengjie., Pan, Hao., Sun, Hongwei., ... & Kong, Hongru. (2021). Development and Evaluation of Nomograms to Predict the Cancer-Specific Mortality and Overall Mortality of Patients with Hepatocellular Carcinoma. BIOMED RESEARCH INTERNATIONAL, 2021, 1658403.
MLA Ni, Xiaofeng,et al."Development and Evaluation of Nomograms to Predict the Cancer-Specific Mortality and Overall Mortality of Patients with Hepatocellular Carcinoma".BIOMED RESEARCH INTERNATIONAL 2021(2021):1658403.

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