The independent association of mean platelet volume with overall survival in multiple myeloma

doi:10.18632/oncotarget.11551

科研成果详情

题名	The independent association of mean platelet volume with overall survival in multiple myeloma
作者	Zhuang, Qiang1; Xiang, Lina2; Xu, Hanyan3; Fang, Fang 1; Xing, Chongyun1; Liang, Bin1; Yu, Kang1; Feng, Jianhua1,4
发表日期	2016-09-20
发表期刊	ONCOTARGET 影响因子和分区
语种	英语
原始文献类型	Article
关键词	multiple myeloma mean platelet volume prognosis survival
其他关键词	UNDETERMINED SIGNIFICANCE ; MONOCLONAL GAMMOPATHY ; MYOCARDIAL-INFARCTION ; THROMBOSIS ; SIZE ; POPULATIONS ; EVENTS ; CANCER ; RISK
摘要	We retrospectively analyzed the association between mean platelet volume (MPV) and prognosis in 62 newly diagnosed multiple myeloma (MM) patients. The associations between MPV and clinical characteristics were assessed. The log-rank test and the Cox proportional hazards model were used to evaluate the effect of MPV on survival. A MPV value of 8.50 fl was considered to be the optimal cut-off value for prognosis. MPV was associated with IgA isotype (P=0.012), serum creatinine concentration > 176.8 mu mol/L (P=0.025) and IgH rearrangement (P=0.008). The log-rank test demonstrated that patients with low MPV experienced a shorter overall survival (OS) (P=0.0397). The multivariate analysis demonstrated that low MPV was an independent prognostic factor for OS [hazard ratio (HR)=2.44, P=0.026]. Therefore, we demonstrated that low MPV predicted an unfavorable prognosis in patients with MM.
资助项目	Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [LQ14H080002, LY12H08002]
出版者	IMPACT JOURNALS LLC
出版地	ORCHARD PARK
ISSN	1949-2553
EISSN	1949-2553
卷号	7 期号:38 页码:62640-62646
DOI	10.18632/oncotarget.11551
页数	7
WOS类目	Oncology ; Cell Biology
WOS研究方向	Oncology ; Cell Biology
WOS记录号	WOS:000387164700137
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	27566590
PMC记录号	PMC5308753
SCOPUSEID	2-s2.0-84991746083
通讯作者地址	[Feng, Jianhua]Department of Hematology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Oncology
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/11970
专题	附属第一医院_血液内科第一临床医学院（信息与工程学院）、附属第一医院_急诊医学
通讯作者	Feng, Jianhua
作者单位	1.Department of Hematology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 2.Department of Emergency Medicine,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 3.Department of Pneumology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 4.Department of Pediatric Hematology-Oncology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zhuang, Qiang,Xiang, Lina,Xu, Hanyan,et al. The independent association of mean platelet volume with overall survival in multiple myeloma[J]. ONCOTARGET,2016,7(38):62640-62646.
APA	Zhuang, Qiang., Xiang, Lina., Xu, Hanyan., Fang, Fang., Xing, Chongyun., ... & Feng, Jianhua. (2016). The independent association of mean platelet volume with overall survival in multiple myeloma. ONCOTARGET, 7(38), 62640-62646.
MLA	Zhuang, Qiang,et al."The independent association of mean platelet volume with overall survival in multiple myeloma".ONCOTARGET 7.38(2016):62640-62646.