Helicobacter pylori infection with intestinal metaplasia: An independent risk factor for colorectal adenomas

doi:10.3748/wjg.v23.i8.1443

科研成果详情

题名	Helicobacter pylori infection with intestinal metaplasia: An independent risk factor for colorectal adenomas
作者	Yan, Ye1; Chen, Yi-Na 1; Zhao, Qian1; Chen, Chao 1; Lin, Chun-Jing2; Jin, Yin1; Pan, Shuang1; Wu, Jian-Sheng2
发表日期	2017-02-28
发表期刊	WORLD JOURNAL OF GASTROENTEROLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Helicobacter pylori Chinese population Colorectal neoplasms Intestinal metaplasia Chronic gastritis
其他关键词	CANCER RISK ; COLONIC NEOPLASMS ; SERUM GASTRIN ; SEROPREVALENCE ; HYPERGASTRINEMIA ; PROGRESSION ; CARCINOMA ; GERMANY ; POLYPS
摘要	AIM To explore the association between Helicobacter pylori (H. pylori) infection status, intestinal metaplasia (IM), and colorectal adenomas. METHODS We retrospectively reviewed 1641 individuals aged >= 40 years who underwent physical examination, laboratory testing, C-13-urea breath testing, gastroscopy, colonoscopy, and an interview to ascertain baseline characteristics and general state of health. Histopathological results were obtained by gastric and colorectal biopsies. RESULTS The prevalence of H. pylori infection and adenomas was 51.5% (845/1641) and 18.1% (297/1641), respectively. H. pylori infection was significantly correlated with an increased risk of colorectal adenomas (crude OR = 1.535, 95% CI: 1.044-1.753, P = 0.022; adjusted OR = 1.359, 95% CI: 1.035-1.785, P = 0.028). Individuals with IM had an elevated risk of colorectal adenomas (crude OR = 1.664, 95% CI: 1.216-2.277, P = 0.001; adjusted OR = 1.381, 95% CI: 0.998-1.929, P = 0.059). Stratification based on H. pylori infection stage and IM revealed that IM accompanied by H. pylori infection was significantly associated with an increased risk of adenomas (crude OR = 2.109, 95% CI: 1.383-3.216, P = 0.001; adjusted OR = 1.765, 95% CI: 1.130-2.757, P = 0.012). CONCLUSION H. pylori-related IM is associated with a high risk of colorectal adenomas in Chinese individuals.
出版者	BAISHIDENG PUBLISHING GROUP INC
出版地	PLEASANTON
ISSN	1007-9327
EISSN	2219-2840
卷号	23 期号:8 页码:1443-1449
DOI	10.3748/wjg.v23.i8.1443
页数	7
WOS类目	Gastroenterology & Hepatology
WOS研究方向	Gastroenterology & Hepatology
WOS记录号	WOS:000395823500014
收录类别	SCIE ; PUBMED ; 万方 ; SCOPUS
URL	查看原文
PubMed ID	28293091
PMC记录号	PMC5330829
SCOPUSEID	2-s2.0-85015017672
通讯作者地址	[Wu, Jian-Sheng]Medical and Health Care Center,First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang Province,325000,China
Scopus学科分类	Gastroenterology
引用统计	被引频次：13[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/11956
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_医疗保健中心
通讯作者	Wu, Jian-Sheng
作者单位	1.Department of Gastroenterology,First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang Province,325000,China; 2.Medical and Health Care Center,First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang Province,325000,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Yan, Ye,Chen, Yi-Na,Zhao, Qian,et al. Helicobacter pylori infection with intestinal metaplasia: An independent risk factor for colorectal adenomas[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2017,23(8):1443-1449.
APA	Yan, Ye., Chen, Yi-Na., Zhao, Qian., Chen, Chao., Lin, Chun-Jing., ... & Wu, Jian-Sheng. (2017). Helicobacter pylori infection with intestinal metaplasia: An independent risk factor for colorectal adenomas. WORLD JOURNAL OF GASTROENTEROLOGY, 23(8), 1443-1449.
MLA	Yan, Ye,et al."Helicobacter pylori infection with intestinal metaplasia: An independent risk factor for colorectal adenomas".WORLD JOURNAL OF GASTROENTEROLOGY 23.8(2017):1443-1449.

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