Effects of Th17 cells and IL-17 in the progression of cervical carcinogenesis with high-risk human papillomavirus infection

doi:10.1002/cam4.1279

科研成果详情

题名	Effects of Th17 cells and IL-17 in the progression of cervical carcinogenesis with high-risk human papillomavirus infection
作者	Xue, JiSen1; Wang, YuLi1; Chen, Cheng 2; Zhu, XueJie1; Zhu, Hua 1; Hu, Yan1
发表日期	2018-02
发表期刊	CANCER MEDICINE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Cervical lesions human papillomavirus IL-17 T-cell immunity Th17 cells
其他关键词	T-CELLS ; CANCER ; INFLAMMATION ; EXPRESSION ; DISTINCT ; LINEAGE
摘要	The existence of Th17 cells and IL-17 was recently shown in several types of infectious diseases, but their distribution and functions in cervical lesions with high-risk human papillomavirus (HPV) infection have not been fully elucidated. In this study, the frequency of Th17 cells in peripheral blood samples obtained from 28 cervical squamous cell carcinoma patients, 26 CIN1 patients, 30 CIN2 patients, 29 CIN3 patients, 25 high-risk HPV-infected women with normal cervical cytology, and 30 healthy controls was determined by flow cytometry. Besides, the levels of IL-17 in peripheral blood samples as well as in supernatant of cervical tissue homogenate were assessed by enzyme-linked immunosorbent assay (ELISA) simultaneously. We found that during the disease progression of cervical lesions, the proportion of Th17 cells in the total CD4(+) cells showed a gradually increased tendency compared with the controls (P < 0.05). Moreover, levels of IL-17 in serum and supernatant of cervical tissue homogenate showed the same tendency as the proportion of Th17 cells (P < 0.05). When compared in pairs, the levels of IL-17 in supernatant differed significantly among the study groups and the control group (P < 0.05), but no significant difference was observed in serum (P > 0.05). In conclusions, the results indicate that Th17 cells and IL-17 may play a role of immune enhancement in the infection of high-risk HPV especially in the cervical microenvironment, which contribute to the disease progression of its associated cervical lesions.
资助项目	Zhejiang Provincial Health Department Foundation of China [2011KYA107]; Wenzhou science and Technology Bureau project [Y20170119]
出版者	WILEY
出版地	HOBOKEN
ISSN	2045-7634
卷号	7 期号:2 页码:297-306
DOI	10.1002/cam4.1279
页数	10
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000424713800002
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	29277958
PMC记录号	PMC5806118
SCOPUSEID	2-s2.0-85038956890
通讯作者地址	[Zhu, Hua]The Department of Gynecology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Oncology;Radiology, Nuclear Medicine and Imaging;Cancer Research
引用统计	被引频次：29[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/11930
专题	第一临床医学院（信息与工程学院）、附属第一医院_妇产科学_妇科附属第二医院附属第一医院第二临床医学院、附属第二医院、育英儿童医院
通讯作者	Zhu, Hua
作者单位	1.The Department of Gynecology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 2.The Department of Gynecology,The Second Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Xue, JiSen,Wang, YuLi,Chen, Cheng,et al. Effects of Th17 cells and IL-17 in the progression of cervical carcinogenesis with high-risk human papillomavirus infection[J]. CANCER MEDICINE,2018,7(2):297-306.
APA	Xue, JiSen, Wang, YuLi, Chen, Cheng, Zhu, XueJie, Zhu, Hua, & Hu, Yan. (2018). Effects of Th17 cells and IL-17 in the progression of cervical carcinogenesis with high-risk human papillomavirus infection. CANCER MEDICINE, 7(2), 297-306.
MLA	Xue, JiSen,et al."Effects of Th17 cells and IL-17 in the progression of cervical carcinogenesis with high-risk human papillomavirus infection".CANCER MEDICINE 7.2(2018):297-306.