MicroRNA-488-3p inhibits proliferation and induces apoptosis by targeting ZBTB2 in esophageal squamous cell carcinoma

doi:10.1002/jcb.29178

科研成果详情

题名	MicroRNA-488-3p inhibits proliferation and induces apoptosis by targeting ZBTB2 in esophageal squamous cell carcinoma
作者	Yang, Yi 1; Li, He2; He, Zhifeng3; Xie, Deyao3; Ni, Jiangwei 3; Lin, Xiaoming3
发表日期	2019-11
发表期刊	JOURNAL OF CELLULAR BIOCHEMISTRY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	esophageal squamous cell carcinoma miR-488-3p tumor progression zinc finger and BTB domain containing 2
其他关键词	P53 PATHWAY ; PROGRESSION ; INVASION ; GROWTH
摘要	Esophageal squamous cell carcinoma (ESCC) is the eighth most prevalent cancer and the sixth leading cause for cancer-associated mortality. MicroRNAs (miRNAs) are increasingly reported to exert important regulatory functions in human cancers by regulating certain gene expression. miR-488-3p has been identified to be a tumor suppressor in multiple cancers, but its role in ESCC is yet to be investigated. The present study aimed to uncover the biological role and modulatory mechanism of miR-488-3p in ESCC. We first revealed the downregulation of miR-488-3p in ESCC tissues and cell lines. Gain-of-function assays confirmed that miR-488-3p overexpression abrogated proliferation and accelerated apoptosis. Mechanistically, we identified via bioinformatics tool and confirmed that zinc finger and BTB domain containing 2 (ZBTB2) was a target for miR-488-3p. Moreover, miR-488-3p activated the p53 pathway through suppressing ZBTB2. Finally, rescue assays proved that ZBTB2 was involved in the regulation of miR-488-3p on proliferation and apoptosis in ESCC. Additionally, we verified that miR-488-3p had alternate targets in ESCC by confirming the involvement of protein kinase, DNA-activated, catalytic subunit (PRKDC), a known target for miR-488-3p, in miR-488-3p-mediated regulation on ESCC. In sum, this study revealed that miR-488-3p inhibited proliferation and induced apoptosis by targeting ZBTB2 and activating p53 pathway in esophageal squamous cell carcinoma, providing a novel biological target for ESCC.
资助项目	National Nature Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81871966]; Natural Science Foundation of Zhejiang ProvinceNatural Science Foundation of Zhejiang Province [LY15H160062]
出版者	WILEY
出版地	HOBOKEN
ISSN	0730-2312
EISSN	1097-4644
卷号	120 期号:11 页码:18702-18713
DOI	10.1002/jcb.29178
页数	12
WOS类目	Biochemistry & Molecular Biology ; Cell Biology
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
WOS记录号	WOS:000486004800016
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
Pubmed记录号	31243806
Scopus记录号	2-s2.0-85068125260
通讯作者地址	[Lin, Xiaoming]Department of Thoracic Surgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
scopus学科分类	Biochemistry;Molecular Biology;Cell Biology
引用统计	被引频次：22[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/11887
专题	教务处_临床技能实验教学中心（挂靠）附属第一医院
通讯作者	Lin, Xiaoming
作者单位	1.Department of Clinical Skills Center,Wenzhou Medical University,Wenzhou,China; 2.Department of Otolaryngoloy-Head and Neck Surgery,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 3.Department of Thoracic Surgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
第一作者单位	温州医科大学
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Yang, Yi,Li, He,He, Zhifeng,et al. MicroRNA-488-3p inhibits proliferation and induces apoptosis by targeting ZBTB2 in esophageal squamous cell carcinoma[J]. JOURNAL OF CELLULAR BIOCHEMISTRY,2019,120(11):18702-18713.
APA	Yang, Yi, Li, He, He, Zhifeng, Xie, Deyao, Ni, Jiangwei, & Lin, Xiaoming. (2019). MicroRNA-488-3p inhibits proliferation and induces apoptosis by targeting ZBTB2 in esophageal squamous cell carcinoma. JOURNAL OF CELLULAR BIOCHEMISTRY, 120(11), 18702-18713.
MLA	Yang, Yi,et al."MicroRNA-488-3p inhibits proliferation and induces apoptosis by targeting ZBTB2 in esophageal squamous cell carcinoma".JOURNAL OF CELLULAR BIOCHEMISTRY 120.11(2019):18702-18713.