Sex-dependent effects on the gut microbiota and host metabolome in type 1 diabetic mice

doi:10.1016/j.bbadis.2021.166266

科研成果详情

题名	Sex-dependent effects on the gut microbiota and host metabolome in type 1 diabetic mice
作者	Zhang, Xi 1,2; Wang, Die 2; Zheng, Yafei 2; Tu, Yingxin2; Xu, Qingqing 2; Jiang, Haowei 2; Li, Chen 2; Zhao, Liangcai2; Li, Yuping1; Zheng, Hong1,2; Gao, Hongchang1,2
发表日期	2021-12-01
发表期刊	BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Correlation network Diabetes Sex difference Microbiome Metabolomics
其他关键词	AMINO-ACID-METABOLISM ; AUTOIMMUNITY ; DATABASE
摘要	Sexual dimorphism exists in the onset and development of type 1 diabetes (T1D), but its potential pathological mechanism is poorly understood. In the present study, we examined sex-specific changes in the gut microbiome and host metabolome of T1D mice via 16S rRNA gene sequencing and nuclear magnetic resonance (NMR)-based metabolomics approach, and aimed to investigate potential mechanism of the gut microbiota-host metabolic interaction in the sexual dimorphism of T1D. Our results demonstrate that female mice had a greater shift in the gut microbiota than male mice during the development of T1D; however, host metabolome was more susceptible to T1D in male mice. The correlation network analysis indicates that T1D-induced host metabolic changes may be regulated by the gut microbiota in a sex-specific manner, mainly involving short-chain fatty acids (SCFAs) metabolism, energy metabolism, amino acid metabolism, and choline metabolism. Therefore, our study suggests that sex-dependent gut microbiota-host metabolism axis may be implicated in the sexual dimorphism of T1D, and the link between microbes and metabolites might contribute to the prevention and treatment of T1D.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21974096, 22074106, 82000384]
出版者	ELSEVIER
出版地	AMSTERDAM
ISSN	0925-4439
EISSN	1879-260X
卷号	1867 期号:12 页码:166266
DOI	10.1016/j.bbadis.2021.166266
页数	12
WOS类目	Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
WOS记录号	WOS:000697154300020
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	34481869
SCOPUSEID	2-s2.0-85114141176
通讯作者地址	[Zheng, Hong]Department of Pulmonary and Critical Care Medicine,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325035,China
Scopus学科分类	Molecular Medicine;Molecular Biology
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/11845
专题	第一临床医学院（信息与工程学院）、附属第一医院_内科学_呼吸与危重症医学科药学院（分析测试中心）附属第一医院附属第二医院_核磁共振室
通讯作者	Zheng, Hong
作者单位	1.Department of Pulmonary and Critical Care Medicine,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325015,China; 2.Institute of Metabonomics & Medical NMR,School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,325035,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 药学院（分析测试中心）
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zhang, Xi,Wang, Die,Zheng, Yafei,et al. Sex-dependent effects on the gut microbiota and host metabolome in type 1 diabetic mice[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,2021,1867(12):166266.
APA	Zhang, Xi., Wang, Die., Zheng, Yafei., Tu, Yingxin., Xu, Qingqing., ... & Gao, Hongchang. (2021). Sex-dependent effects on the gut microbiota and host metabolome in type 1 diabetic mice. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1867(12), 166266.
MLA	Zhang, Xi,et al."Sex-dependent effects on the gut microbiota and host metabolome in type 1 diabetic mice".BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1867.12(2021):166266.