Paclitaxel induces apoptosis of esophageal squamous cell carcinoma cells by downregulating STAT3 phosphorylation at Ser727

doi:10.3892/or.2017.5503

科研成果详情

题名	Paclitaxel induces apoptosis of esophageal squamous cell carcinoma cells by downregulating STAT3 phosphorylation at Ser727
作者	Zhang, Xiaolong1,2; Wu, Xiaoyi 2; Zhang, Fangling 3; Mo, Shouyong2,4; Lu, Yuanyuan2; Wei, Wei 2; Chen, Xiaoling 2; Lan, Linhua2; Lu, Bin 2; Liu, Yongzhang2
发表日期	2017-04
发表期刊	ONCOLOGY REPORTS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	paclitaxel esophageal squamous cell carcinoma STAT3 apoptosis mitochondria
其他关键词	MITOCHONDRIAL STAT3 ; CANCER-MORTALITY ; PHASE-II ; TAXOL ; FLUOROURACIL ; INDUCTION ; CISPLATIN
摘要	Paclitaxel induces apoptosis in a variety of cancer cells. However, the mechanism of paclitaxel inducing apoptosis in human esophageal squamous cell carcinoma (ESCC) remains to be defined. In this study, we found that paclitaxelinduced apoptosis by increasing the relevant apoptosis protein expression and the release of cytochrome c via downregulation of signal transducer and activator of transcription 3 (STAT3) and phospho-STAT3 (Ser727). In addition, paclitaxel treatment of ESCC cells EC -1 and Eca-109 led to marked mitochondrial membrane potential depolarization and significantly increasing of reactive oxygen species. Moreover, paclitaxel treatment resulted in the inhibition of mitochondrial respiration. In conclusion, our findings reveal that paclitaxel induced apoptosis in both EC -1 and Eca-109 cells through the reduction of STAT3 and phospho-STAT3 (Ser727) level, and suggest that paclitaxel may be of therapeutic potential in the treatment of ESCC through the induction of mitochondrial apoptosis in ESCC cells.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31171345, 31570772]; Natural Science Foundation of Zhejiang ProvinceNatural Science Foundation of Zhejiang Province [LY17C070005]
出版者	SPANDIDOS PUBL LTD
出版地	ATHENS
ISSN	1021-335X
EISSN	1791-2431
卷号	37 期号:4 页码:2237-2244
DOI	10.3892/or.2017.5503
页数	8
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000398138900038
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	28350087
SCOPUSEID	2-s2.0-85016429782
通讯作者地址	[Lu, Bin]Protein Quality Control and Diseases Laboratory,Cancer Center,Wenzhou Medical University,Wenzhou, Zhejiang,325035,China
Scopus学科分类	Oncology;Cancer Research
引用统计	被引频次：15[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/11760
专题	第二临床医学院，附属第二医院、育英儿童医院温州医科大学其他_浙江省肿瘤医院（浙江省癌症中心）
通讯作者	Lu, Bin
作者单位	1.Department of Anesthesia and Critical Care,Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou, Zhejiang,325027,China; 2.Protein Quality Control and Diseases Laboratory,Cancer Center,Wenzhou Medical University,Wenzhou, Zhejiang,325035,China; 3.Second Clinical Medical School,Wenzhou Medical University,Wenzhou, Zhejiang,325035,China; 4.Fifth Affiliated Hospital of Wenzhou Medical University,Lishui, Zhejiang,323000,China
第一作者单位	第二临床医学院，附属第二医院、育英儿童医院; 其他_浙江省肿瘤医院（浙江省癌症中心）
通讯作者单位	其他_浙江省肿瘤医院（浙江省癌症中心）
第一作者的第一单位	第二临床医学院，附属第二医院、育英儿童医院
推荐引用方式 GB/T 7714	Zhang, Xiaolong,Wu, Xiaoyi,Zhang, Fangling,et al. Paclitaxel induces apoptosis of esophageal squamous cell carcinoma cells by downregulating STAT3 phosphorylation at Ser727[J]. ONCOLOGY REPORTS,2017,37(4):2237-2244.
APA	Zhang, Xiaolong., Wu, Xiaoyi., Zhang, Fangling., Mo, Shouyong., Lu, Yuanyuan., ... & Liu, Yongzhang. (2017). Paclitaxel induces apoptosis of esophageal squamous cell carcinoma cells by downregulating STAT3 phosphorylation at Ser727. ONCOLOGY REPORTS, 37(4), 2237-2244.
MLA	Zhang, Xiaolong,et al."Paclitaxel induces apoptosis of esophageal squamous cell carcinoma cells by downregulating STAT3 phosphorylation at Ser727".ONCOLOGY REPORTS 37.4(2017):2237-2244.