trans-Resveratrol Ameliorates Stress-Induced Irritable Bowel Syndrome-Like Behaviors by Regulation of Brain-Gut Axis

doi:10.3389/fphar.2018.00631

科研成果详情

题名	trans-Resveratrol Ameliorates Stress-Induced Irritable Bowel Syndrome-Like Behaviors by Regulation of Brain-Gut Axis
作者	Xu, Ying 1,2; Cui, Su-Ying 2,3; Ma, Quan 2; Shi, Jing 4; Yu, Ying 1; Li, Jian-Xin1; Zheng, Liang 1; Zhang, Yi 2; Si, Jian-Min 5; Yu, Ying-Cong1,5
发表日期	2018-06-15
发表期刊	FRONTIERS IN PHARMACOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	irritable bowel syndrome depression anxiety trans-Resveratrol phosphodiesterases 4A
其他关键词	PHOSPHODIESTERASE-5 INHIBITOR SILDENAFIL ; DEPRESSIVE-LIKE BEHAVIOR ; CENTRAL-NERVOUS-SYSTEM ; CHRONIC MILD STRESS ; ANTIDEPRESSANT-LIKE ; VISCERAL HYPERSENSITIVITY ; COLORECTAL DISTENSION ; RAT HIPPOCAMPUS ; KNOCK-DOWN ; HPA AXIS
摘要	Background: Irritable bowel syndrome (IBS) is a functional disorder characterized by abdominal pain and abnormalities in defecation associated with psychiatric disorders such as depression and anxiety due to the dysfunction of brain-gut axis. This study aims to determine whether trans-Resveratrol affects chronic-acute combined stress (CACS)-induced IBS-like symptoms including depression, anxiety and intestinal dysfunction. Methods: ICR male mice were exposed to the CACS for 3 weeks. trans-Resveratrol were administrated daily (2.5, 5, and 10 mg/kg, i.g.) 30 min before CACS. Behavioral tests were performed to evaluate the treatment effects of trans-Resveratrol on IBS. Hippocampus tissues were collected and processed Golgi staining and immuno-blot analysis. Ileum and colon tissues were collected and processed Hematoxylin and Eosin staining and immuno-blot analysis. Results: Administration with trans-Resveratrol before CACS for 3 weeks significantly reversed CACS-induced depression- and anxiety-like behaviors and intestinal dysfunction in mice, which implied a crucial role of trans-Resveratrol in treatment of IBS-like disorder. Furthermore, trans-Resveratrol improved hippocampal neuronal remodeling, protected ileal and colonic epithelial barrier structure against CACS insults. The further study suggested that trans-Resveratrol normalized phosphodiesterases 4A (PDE4A) expression and CREB-BDNF signaling that were disturbed by CACS. The increased pCREB and BDNF expression in the hippocampus were found, while decreased pCREB and BDNF levels were observed after treatment with trans-Resveratrol. Conclusions: The dual effects of trans-Resveratrol on stress-induced psychiatric and intestinal dysfunction may be related to normalization of PDE4A expression and subsequent pCREB-BDNF signaling in the hippocampus, ileum and colon.
资助项目	National Natural Science Foundation for the YouthNational Natural Science Foundation of China (NSFC) [NSFY 81400600]; Foundation from Wenzhou Science and Technology Bureau [H20150004]; Zhejiang province key science and technology innovation team [2013TD13]
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
ISSN	1663-9812
卷号	9 期号:JUN 页码:631
DOI	10.3389/fphar.2018.00631
页数	13
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:000435364800001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	29962949
PMC记录号	PMC6013570
SCOPUSEID	2-s2.0-85048573628
通讯作者地址	[Yu, Ying-Cong]Department of Gastroenterology,Wenzhou No. 3 Clinical Institute Affiliated to Wenzhou Medical University,Wenzhou People's Hospital,Wenzhou,China
Scopus学科分类	Pharmacology;Pharmacology (medical)
引用统计	被引频次：13[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/11526
专题	温州医科大学
通讯作者	Yu, Ying-Cong
作者单位	1.Department of Gastroenterology,Wenzhou No. 3 Clinical Institute Affiliated to Wenzhou Medical University,Wenzhou People's Hospital,Wenzhou,China; 2.Departments of Pharmaceutical Sciences,School of Pharmacy and Pharmaceutical Sciences,State University of New York at Buffalo,Buffalo,United States; 3.Department of Pharmacology,Peking University,School of Basic Medical Science,Beijing,China; 4.School of Pharmacy,Hangzhou Medical College,Hangzhou,China; 5.Institute of Gastroenterology,Zhejiang University,Hangzhou,China
第一作者单位	温州医科大学
通讯作者单位	温州医科大学
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Xu, Ying,Cui, Su-Ying,Ma, Quan,et al. trans-Resveratrol Ameliorates Stress-Induced Irritable Bowel Syndrome-Like Behaviors by Regulation of Brain-Gut Axis[J]. FRONTIERS IN PHARMACOLOGY,2018,9(JUN):631.
APA	Xu, Ying., Cui, Su-Ying., Ma, Quan., Shi, Jing., Yu, Ying., ... & Yu, Ying-Cong. (2018). trans-Resveratrol Ameliorates Stress-Induced Irritable Bowel Syndrome-Like Behaviors by Regulation of Brain-Gut Axis. FRONTIERS IN PHARMACOLOGY, 9(JUN), 631.
MLA	Xu, Ying,et al."trans-Resveratrol Ameliorates Stress-Induced Irritable Bowel Syndrome-Like Behaviors by Regulation of Brain-Gut Axis".FRONTIERS IN PHARMACOLOGY 9.JUN(2018):631.