Simultaneous determination of evodiamine and rutecarpine in rabbit plasma by LC-ESI-MS and its application to pharmacokinetics

doi:10.1691/ph.2011.1075

科研成果详情

题名	Simultaneous determination of evodiamine and rutecarpine in rabbit plasma by LC-ESI-MS and its application to pharmacokinetics
作者	Lin, Chongliang1; Pan, Xiaojun 2; Li, Wei 1; Ma, Jianshe3; Pan, Jingye1; Cai, Jinzhang4; Wang, Xianqin2; Lin, Guanyang1
发表日期	2011-12
发表期刊	PHARMAZIE 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	TANDEM MASS-SPECTROMETRY ; HYDROCHLORIDE
摘要	A sensitive and selective liquid chromatography-mass spectrometry (LC-MS) method for the determination of evodiamine and rutecarpine in rabbit plasma was developed and validated. The analytes and internal standard (IS) are extracted from plasma by one-step protein precipitation with acetonitrile, and separated on a Zorbax SB-C18 column (2.1 mm x 50 mm, 3.5 mu m) using acetonitrile-0.1% formic acid as mobile phase with gradient elution. Electrospray ionization (ESI) source was applied and operated in positive ion mode, and selective ion monitoring (SIM) mode used to quantify evodiamine and rutecarpine. The assay is linear over the range of 2-1600 ng/mL for evodiamine and rutecarpine, with a lower limit of quantification (LLOQ) of 5 ng/mL both for evodiamine and rutecarpine. Intra-day and inter-day precision are less than 12% and the accuracy are in the range of 90.9-104.3%. Furthermore, the newly developed method is successfully used for the determination of evodiamine and rutecarpine in rabbit plasma for pharmacokinetic study.
出版者	GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH
出版地	ESCHBORN
ISSN	0031-7144
卷号	66 期号:12 页码:920-923
DOI	10.1691/ph.2011.1075
页数	4
WOS类目	Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy ; Chemistry
WOS记录号	WOS:000298937100003
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	22312694
SCOPUSEID	2-s2.0-84862922006
通讯作者地址	[Lin, Guanyang]Wenzhou Med Coll, Affiliated Hosp 1, Fuxue Lane 2, Wenzhou 325000, Peoples R China.
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/1150
专题	附属第一医院附属第二医院第二临床医学院、附属第二医院、育英儿童医院基础医学院（机能实验教学中心）_基础医学实验教学中心_机能实验教学中心（挂靠、校级）
通讯作者	Lin, Guanyang
作者单位	1.Wenzhou Med Coll, Affiliated Hosp 1, Wenzhou 325000, Peoples R China; 2.Wenzhou Med Coll, Analyt & Testing Ctr, Wenzhou 325000, Peoples R China; 3.Wenzhou Med Coll, Funct Expt Teaching Ctr, Wenzhou 325000, Peoples R China; 4.Wenzhou Med Coll, Affiliated Hosp 2, Wenzhou 325000, Peoples R China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Lin, Chongliang,Pan, Xiaojun,Li, Wei,et al. Simultaneous determination of evodiamine and rutecarpine in rabbit plasma by LC-ESI-MS and its application to pharmacokinetics[J]. PHARMAZIE,2011,66(12):920-923.
APA	Lin, Chongliang., Pan, Xiaojun., Li, Wei., Ma, Jianshe., Pan, Jingye., ... & Lin, Guanyang. (2011). Simultaneous determination of evodiamine and rutecarpine in rabbit plasma by LC-ESI-MS and its application to pharmacokinetics. PHARMAZIE, 66(12), 920-923.
MLA	Lin, Chongliang,et al."Simultaneous determination of evodiamine and rutecarpine in rabbit plasma by LC-ESI-MS and its application to pharmacokinetics".PHARMAZIE 66.12(2011):920-923.