FP3: A Novel VEGF Blocker with Anti-Angiogenic and Anti-Tumor Effects

doi:10.5754/hge12159

科研成果详情

题名	FP3: A Novel VEGF Blocker with Anti-Angiogenic and Anti-Tumor Effects
作者	Gao, Weili 1; Jin, Ketao 2,3,4,7; Lan, Huanrong 5; Han, Na 6; Cao, Feilin2; Teng, Lisong 3
发表日期	2012-11
发表期刊	HEPATO-GASTROENTEROLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	FP3 Vascular endothelial growth factor (VEGF) Angiogenesis Antiangiogenic effect Anti-tumor effect
其他关键词	ENDOTHELIAL GROWTH-FACTOR ; LIVER METASTASES ; IN-VITRO ; CANCER ; CELLS ; AFLIBERCEPT ; COMBINATION ; MELANOMA ; THERAPY
摘要	Background/Aims: Vascular endothelial growth factor (VEGF) serves as a logical target for antiangiogenic cancer therapy. This study is to investigate the inhibitory effects of FP3, a novel VEGF blocker, on angiogenesis in vitro and in vivo as well as anti-tumor effects on a liver cancer xenograft model in vivo. Methodology: The inhibitory effects of FP3 on angiogenesis were assessed by using human umbilical vein endothelial cells (HUVECs) in vitro and the chick embryo chorioallantoic membrane (CAM) in vivo. The inhibitory effect of FP3 on tumor growth in vivo were evaluated in a human liver cancer cell line Hep-3B xenograft model in nude mice with the methods of tumor growth regression assay. Results: In experiments with HUVECs, FP3 inhibited cell survival and tube formation. In CAM assay, FP3 suppressed MCF-7 human breast cancer cell-induced angiogenesis. In tumor growth regression assay, FP3 significantly blocked the growth of Hep-3B tumor cell in subcutaneous tumor xenograft model in nude mice. Conclusions: FP3 has excellent inhibitory effects on angiogenesis both in vitro and in vivo and antitumor effect on liver cancer xenograft model; therefore, it might be used as an effective antiangiogenic agent in treatment of liver cancer.
资助项目	National High-tech Research & Development Program of China (863 Program)National High Technology Research and Development Program of China [2006AA02A245]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81000894]; Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [Y12H160045]; Zhejiang Provincial Science and Technology Projects [2009C13021, 2011C23087]; Zhejiang Provincial Medical and Healthy Science and Technology Projects [2011KYB137]; Science Research Fund of Taizhou [A102KY09]; Science Research Fund of Shaoxing [2011D10013]; Science Research Fund of Zhuji [2011CC7874]; State Key Basic Research and Development Program of China (973 Program)National Basic Research Program of China [2009CB521704]
出版者	H G E UPDATE MEDICAL PUBLISHING S A
出版地	ATHENS
ISSN	0172-6390
卷号	59 期号:120 页码:2543-2547
DOI	10.5754/hge12159
页数	5
WOS类目	Gastroenterology & Hepatology ; Surgery
WOS研究方向	Gastroenterology & Hepatology ; Surgery
WOS记录号	WOS:000312689300042
收录类别	SCIE ; SCOPUS
URL	查看原文
PubMed ID	22534543
SCOPUSEID	2-s2.0-84872086401
通讯作者地址	[Jin, Ketao]Department of Surgical Oncology,Taizhou Hospital,Wenzhou Medical College,China
Scopus学科分类	Hepatology;Gastroenterology
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/11417
专题	其他_附属台州医院（浙江省台州医院）第一临床医学院（信息与工程学院）、附属第一医院_外科学_肿瘤外科其他_附属诸暨医院（诸暨市人民医院）
通讯作者	Jin, Ketao
作者单位	1.Department of General Surgery,Huzhou Central Hospital,China; 2.Department of Surgical Oncology,Taizhou Hospital,Wenzhou Medical College,China; 3.Department of Surgical Oncology,College of Medicine,Zhejiang University,China; 4.Department of Surgery,Zhuji Hospital,Wenzhou Medical College,China; 5.Department of Gynecology and Obstetrics,Taizhou Hospital,Wenzhou Medical College,China; 6.Cancer Chemotherapy Center,Zhejiang Cancer Hospital,Zhejiang University of Chinese Medicine,China; 7.Department of Surgical Oncology,Zhuji Hospital,Wenzhou Medical College,150, Ximen Road,China
通讯作者单位	附属台州医院（浙江省台州医院）; 附属台州医院
推荐引用方式 GB/T 7714	Gao, Weili,Jin, Ketao,Lan, Huanrong,et al. FP3: A Novel VEGF Blocker with Anti-Angiogenic and Anti-Tumor Effects[J]. HEPATO-GASTROENTEROLOGY,2012,59(120):2543-2547.
APA	Gao, Weili, Jin, Ketao, Lan, Huanrong, Han, Na, Cao, Feilin, & Teng, Lisong. (2012). FP3: A Novel VEGF Blocker with Anti-Angiogenic and Anti-Tumor Effects. HEPATO-GASTROENTEROLOGY, 59(120), 2543-2547.
MLA	Gao, Weili,et al."FP3: A Novel VEGF Blocker with Anti-Angiogenic and Anti-Tumor Effects".HEPATO-GASTROENTEROLOGY 59.120(2012):2543-2547.