Embryonic stem cell factors and pancreatic cancer

doi:10.3748/wjg.v20.i9.2247

科研成果详情

题名	Embryonic stem cell factors and pancreatic cancer
作者	Herreros-Villanueva, Marta 1,2; Bujanda, Luis 2; Billadeau, Daniel D.1; Zhang, Jin-San1,3
发表日期	2014-03-07
发表期刊	WORLD JOURNAL OF GASTROENTEROLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Embryonic stem cells NANOG SOX2 OCT4 Pluripotency Pancreatic cancer Cancer stem cells
其他关键词	SELF-RENEWAL ; GEMCITABINE RESISTANCE ; MYELOID-LEUKEMIA ; NANOG EXPRESSION ; C-MET ; IDENTIFICATION ; PLURIPOTENCY ; MOUSE ; OCT4 ; DIFFERENTIATION
摘要	Pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic tumor, is a highly aggressive human cancer with the lowest five-year survival rate of any human maligancy primarily due to its early-metastasis and lack of response to chemotherapy and radiation. Recent research suggests that PDAC cells comprise a hierarchy of tumor cells that develop around a population of cancer stem cells (CSCs), a small and distinct population of cancer cells that mediates tumoregenesis, metastasis and resistance to standard treatments. Thus, CSCs could be a target for more effective treatment options. Interestingly, pancreatic CSCs are subject to regulation by some of key embryonic stem cell (ESC) transctiption factors abberently expressed in PDAC, such as SOX2, OCT4 and NANOG. ESC transcription factors are important DNA-binding proteins present in both embryonic and adult somatic cells. The critical role of these factors in reprogramming processes makes them essential not only for embryonic development but also tumorigenesis. Here we provide an overview of stem cell transcription factors, particularly SOX2, OCT4, and NANOG, on their expression and function in pancreatic cancer. In contrast to embryonic stem cells, in which OCT4 and SOX2 are tightly regulated and physically interact to regulate a wide spectrum of target genes, de novo SOX2 expression alone in pancreatic cancer cells is sufficient to promote self-renewal, de-differentiation and imparting stemness characteristics via impacting specific cell cycle regulatory genes and epithelial-mesnechymal transtion driver genes. Thus, targeting ESC factors, particularly SOX2, could be a worthy strategy for pancreatic cancer therapy. (C) 2014 Baishideng Publishing Group Co., Limited. All rights reserved.
资助项目	Universidad del Pais Vasco, Instituto Biodonostia, San Sebastian; CIBERehd (red de enfermedades hepaticas y digestivas); American Cancer Society institutional awardAmerican Cancer Society; Mayo Clinic Pancreatic Cancer SPORE [CA102701]; NATIONAL CANCER INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [P20CA102701, P50CA102701] Funding Source: NIH RePORTER
出版者	BAISHIDENG PUBLISHING GROUP INC
出版地	PLEASANTON
ISSN	1007-9327
EISSN	2219-2840
卷号	20 期号:9 页码:2247-2254
DOI	10.3748/wjg.v20.i9.2247
页数	8
WOS类目	Gastroenterology & Hepatology
WOS研究方向	Gastroenterology & Hepatology
WOS记录号	WOS:000332692300014
收录类别	SCIE ; SCOPUS
URL	查看原文
Pubmed记录号	24605024
Scopus记录号	2-s2.0-84895858886
通讯作者地址	[Zhang, Jin-San]Division of Oncology Research,Schulze Center for Novel Therapeutics,Mayo Clinic College of Medicine,United States
scopus学科分类	Gastroenterology
引用统计	被引频次：57[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/11389
专题	药学院（分析测试中心）_生物制药系_生物制药工程
通讯作者	Zhang, Jin-San
作者单位	1.Division of Oncology Research,Schulze Center for Novel Therapeutics,Mayo Clinic College of Medicine,United States; 2.Department of Gastroenterology,Hospital Donostia/Instituto Biodonostia,Centro de Investigacion Biomedica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd),Universidad del País Vasco UPV/EHU,Spain; 3.School of Pharmaceutical Sciences,Key Laboratory of Biotechnology and Pharmaceutical Engineering,Wenzhou Medical University,China
推荐引用方式 GB/T 7714	Herreros-Villanueva, Marta,Bujanda, Luis,Billadeau, Daniel D.,et al. Embryonic stem cell factors and pancreatic cancer[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2014,20(9):2247-2254.
APA	Herreros-Villanueva, Marta, Bujanda, Luis, Billadeau, Daniel D., & Zhang, Jin-San. (2014). Embryonic stem cell factors and pancreatic cancer. WORLD JOURNAL OF GASTROENTEROLOGY, 20(9), 2247-2254.
MLA	Herreros-Villanueva, Marta,et al."Embryonic stem cell factors and pancreatic cancer".WORLD JOURNAL OF GASTROENTEROLOGY 20.9(2014):2247-2254.

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