The metabolism of steroids, toxins and drugs by 11 beta-hydroxysteroid dehydrogenase 1

doi:10.1016/j.tox.2011.11.012

科研成果详情

题名	The metabolism of steroids, toxins and drugs by 11 beta-hydroxysteroid dehydrogenase 1
作者	Zhou, Hong-Yu1; Hu, Guo-Xin1; Lian, Qing-Quan2; Morris, David 3; Ge, Ren-Shan2,4
发表日期	2012-02-06
发表期刊	TOXICOLOGY 影响因子和分区
语种	英语
原始文献类型	Review
关键词	Glucocorticoid 11 beta-Hydroxysteroid dehydrogenase Carbonyl reduction Redox
其他关键词	BETA-HYDROXYSTEROID DEHYDROGENASE ; RAT LEYDIG-CELLS ; APPARENT MINERALOCORTICOID EXCESS ; ENDOPLASMIC-RETICULUM LUMEN ; MOUSE-LIVER MICROSOMES ; GUINEA-PIG KIDNEY ; HEXOSE-6-PHOSPHATE DEHYDROGENASE ; CARBONYL REDUCTION ; IN-VITRO ; TISSUE DISTRIBUTION
摘要	11 p-Hydroxysteroid dehydrogenase isoform 1 (11 beta-HSD1) is a member of the alcohol short-chain family enzyme, and catalyzes the interconversion between active glucocorticoid cortisol (in human) and inactive cortisone. The redox ratio of NADP+/NADPH determines its direction with NADPH favoring its reductase activity and NADP+ favoring its oxidase activity. In many tissues such as the liver and lung, 11 beta-HSD1 behaves primarily as a reductase because of the intracellular enzyme coupling with hexose-6-phosphate dehydrogenase, which uses the NADP+ as cofactor to supply NADPH driving 11 beta-HSD1 to function as a reductase. 11 beta-HSD1 catalyzes the metabolism of 7- or 11-keto steroids as well as many toxins and drugs. Some steroids, drugs and toxins are metabolically activated. The present review discusses the steroid, drug and toxin metabolism by 11 beta-HSD1. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
资助项目	NSFCNational Natural Science Foundation of China (NSFC) [30871434]; Wenzhou Municipal Science and Technology Bureau [2008H0121, 20090003]
出版者	ELSEVIER IRELAND LTD
出版地	CLARE
ISSN	0300-483X
EISSN	1879-3185
卷号	292 期号:1 页码:1-12
DOI	10.1016/j.tox.2011.11.012
页数	12
WOS类目	Pharmacology & Pharmacy ; Toxicology
WOS研究方向	Pharmacology & Pharmacy ; Toxicology
WOS记录号	WOS:000300531200001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	22154985
SCOPUSEID	2-s2.0-84855298464
通讯作者地址	[Ge, Ren-Shan]Population Council and Rockefeller University,1230 York Avenue,United States
Scopus学科分类	Toxicology
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/11370
专题	药学院（分析测试中心）_临床药学与药理系附属第二医院
通讯作者	Ge, Ren-Shan
作者单位	1.Department of Pharmacology,School of Pharmacy,Wenzhou Medical College,China; 2.The 2nd Affiliated Hospital,Wenzhou Medical College,China; 3.The Miriam Hospital,Brown University School of Medicine,United States; 4.Population Council and Rockefeller University,1230 York Avenue,United States
第一作者单位	药学院（分析测试中心）_临床药学与药理系
第一作者的第一单位	药学院（分析测试中心）_临床药学与药理系
推荐引用方式 GB/T 7714	Zhou, Hong-Yu,Hu, Guo-Xin,Lian, Qing-Quan,et al. The metabolism of steroids, toxins and drugs by 11 beta-hydroxysteroid dehydrogenase 1[J]. TOXICOLOGY,2012,292(1):1-12.
APA	Zhou, Hong-Yu, Hu, Guo-Xin, Lian, Qing-Quan, Morris, David, & Ge, Ren-Shan. (2012). The metabolism of steroids, toxins and drugs by 11 beta-hydroxysteroid dehydrogenase 1. TOXICOLOGY, 292(1), 1-12.
MLA	Zhou, Hong-Yu,et al."The metabolism of steroids, toxins and drugs by 11 beta-hydroxysteroid dehydrogenase 1".TOXICOLOGY 292.1(2012):1-12.