Placental leptin gene methylation and macrosomia during normal pregnancy

doi:10.3892/mmr.2014.1913

科研成果详情

题名	Placental leptin gene methylation and macrosomia during normal pregnancy
作者	Xu, Xinyun 1; Yang, Xinjun1; Liu, Ziwei 1; Wu, Kele2; Liu, Zheng1; Lin, Chong1; Wang, Yuhuan2; Yan, Hongtao1
发表日期	2014-03
发表期刊	MOLECULAR MEDICINE REPORTS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	macrosomia DNA methylation leptin pregnancy placenta
其他关键词	BIRTH-WEIGHT ; MATERNAL OUTCOMES ; DNA METHYLATION ; ADIPOSE-TISSUE ; FETAL-GROWTH ; RISK-FACTORS ; EXPRESSION ; OBESITY ; AGE ; COMPLICATIONS
摘要	The present study examined the placental leptin (LEP) DNA methylation and mRNA levels in macrosomic infants from normal pregnancies. In total, 49 neonates with macrosomia, i.e., high birth weights of 4,000 g, and 52 neonates with normal birth weights between 2,500 g and 4,000 g were recruited from The Second Affiliated Hospital of Wenzhou Medical University (Wenzhou, Zhejiang) in China. Placental LEP promoter methylation and LEP transcript levels were determined by Sequenom MassARRAY and quantitative PCR, respectively. LEP promoter methylation and mRNA levels were not significantly different between the individuals with macrosomia and the controls. However, stratification revealed that individual CpG dinucleotides were hypermethylated in macrosomia (P<0.05) in primiparous females and at 39 weeks of gestation (P<0.05). Variations in methylation did not affect placental LEP expression. It was concluded that the methylation of the placental LEP promoter was altered during a specific gestational period in macrosomia following a normal pregnancy and under certain conditions. However, placental LEP expression was not affected.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81072378]; Natural Science Funds of Zhejiang [Y2101185]
出版者	SPANDIDOS PUBL LTD
出版地	ATHENS
ISSN	1791-2997
EISSN	1791-3004
卷号	9 期号:3 页码:1013-1018
DOI	10.3892/mmr.2014.1913
页数	6
WOS类目	Oncology ; Medicine, Research & Experimental
WOS研究方向	Oncology ; Research & Experimental Medicine
WOS记录号	WOS:000332699000039
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	24452268
SCOPUSEID	2-s2.0-84893862833
通讯作者地址	[Yan, Hongtao]Department of Preventive Medicine,School of Environmental Science and Public Health,Wenzhou Medical University,China
Scopus学科分类	Biochemistry;Molecular Medicine;Molecular Biology;Genetics;Oncology;Cancer Research
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/1136
专题	第二临床医学院，附属第二医院、育英儿童医院附属第二医院
通讯作者	Yan, Hongtao
作者单位	1.Department of Preventive Medicine,School of Environmental Science and Public Health,Wenzhou Medical University,China; 2.Department of Obstetrics and Gynecology,Second Affiliated Hospital of Wenzhou Medical University,China
推荐引用方式 GB/T 7714	Xu, Xinyun,Yang, Xinjun,Liu, Ziwei,et al. Placental leptin gene methylation and macrosomia during normal pregnancy[J]. MOLECULAR MEDICINE REPORTS,2014,9(3):1013-1018.
APA	Xu, Xinyun., Yang, Xinjun., Liu, Ziwei., Wu, Kele., Liu, Zheng., ... & Yan, Hongtao. (2014). Placental leptin gene methylation and macrosomia during normal pregnancy. MOLECULAR MEDICINE REPORTS, 9(3), 1013-1018.
MLA	Xu, Xinyun,et al."Placental leptin gene methylation and macrosomia during normal pregnancy".MOLECULAR MEDICINE REPORTS 9.3(2014):1013-1018.