A Possible Neurodegeneration Mechanism Triggered by Diabetes

doi:10.1016/j.tem.2019.07.012

科研成果详情

题名	A Possible Neurodegeneration Mechanism Triggered by Diabetes
作者	Farhadi, Aisan 1,2; Vosough, Massoud 3; Zhang, Jin-San4,5; Tahamtani, Yaser 1; Shahpasand, Koorosh 6
发表日期	2019-10
发表期刊	TRENDS IN ENDOCRINOLOGY AND METABOLISM 影响因子和分区
语种	英语
原始文献类型	Review
关键词	cis phosphorylated τ diabetes mellitus neurodegeneration.
其他关键词	GLYCATION END-PRODUCTS ; BRAIN INSULIN-RESISTANCE ; ALZHEIMERS-DISEASE ; TAU-HYPERPHOSPHORYLATION ; OXIDATIVE STRESS ; GLUCOSE ; MICE ; RECEPTOR ; PHOSPHORYLATION ; CONFORMATION
摘要	Several conditions result in neurodegeneration; among which diabetes mellitus (DM) is of crucial importance. Tau (tau) malfunction is a major pathological process participating in neurodegeneration. Despite extensive considerations, the actual causative link between DM and tau abnormalities remains uncertain thus far. Phosphorylated (p)-tau at Thr-Pro motifs can exist in the two distinct cis and trans conformations. cis is neurotoxic, and is accumulated upon various stress conditions, such as nutrition depletion. We assume that pathogenic cis p-tau is the central mediator of neurodegeneration in DM, and propose why different areas give various responses to stress conditions. We herein juxtapose recent approaches in diabetic neurodegeneration and propose a therapeutic target to stop neuronal loss during DM.
资助项目	Research and Cognitive Sciences Council, Tehran [96-2154]
出版者	ELSEVIER SCIENCE LONDON
出版地	LONDON
ISSN	1043-2760
EISSN	1879-3061
卷号	30 期号:10 页码:692-700
DOI	10.1016/j.tem.2019.07.012
页数	9
WOS类目	Endocrinology & Metabolism
WOS研究方向	Endocrinology & Metabolism
WOS记录号	WOS:000489015300004
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
Pubmed记录号	31399291
Scopus记录号	2-s2.0-85072791724
自科自定义期刊分类	T3(A)类
通讯作者地址	[Tahamtani, Yaser]Department of Stem Cells and Developmental Biology,Cell Science Research Center,Royan Institute for Stem Cell Biology and Technology,ACECR,Tehran,19395-4644,Iran
scopus学科分类	Endocrinology, Diabetes and Metabolism;Endocrinology
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/11362
专题	卓越中心_国际生长因子研究院药学院（分析测试中心）
通讯作者	Tahamtani, Yaser
作者单位	1.Department of Stem Cells and Developmental Biology,Cell Science Research Center,Royan Institute for Stem Cell Biology and Technology,ACECR,Tehran,19395-4644,Iran; 2.Department of Developmental Biology,University of Science and Culture,Tehran,Iran; 3.Department of Regenerative Biomedicine,Cell Science Research Center,Royan Institute for Stem Cell Biology and Technology,ACECR,Tehran,Iran; 4.International Collaborative Center on Growth Factor Research,School of Pharmaceutical Sciences,Wenzhou Medical University; Institute of Life Sciences,Wenzhou University,Wenzhou,325035,China; 5.Division of Oncology Research,Mayo Clinic,Rochester,55905,United States; 6.Department of Brain and Cognitive Sciences,Cell Science Research Center,Royan Institute for Stem Cell Biology and Technology,ACECR,Tehran,19395-4644,Iran
推荐引用方式 GB/T 7714	Farhadi, Aisan,Vosough, Massoud,Zhang, Jin-San,et al. A Possible Neurodegeneration Mechanism Triggered by Diabetes[J]. TRENDS IN ENDOCRINOLOGY AND METABOLISM,2019,30(10):692-700.
APA	Farhadi, Aisan, Vosough, Massoud, Zhang, Jin-San, Tahamtani, Yaser, & Shahpasand, Koorosh. (2019). A Possible Neurodegeneration Mechanism Triggered by Diabetes. TRENDS IN ENDOCRINOLOGY AND METABOLISM, 30(10), 692-700.
MLA	Farhadi, Aisan,et al."A Possible Neurodegeneration Mechanism Triggered by Diabetes".TRENDS IN ENDOCRINOLOGY AND METABOLISM 30.10(2019):692-700.