Elevated plasma superoxide dismutase in first-episode and drug naive patients with schizophrenia: Inverse association with positive symptoms

doi:10.1016/j.pnpbp.2011.08.018

科研成果详情

题名	Elevated plasma superoxide dismutase in first-episode and drug naive patients with schizophrenia: Inverse association with positive symptoms
作者	Wu, Zhiwei 4; Zhang, Xiang Yang 2,3; Wang, Huanhuan ; Tang, Wei 4; Xia, Yu ; Zhang, FeiXue 4; Liu, Jiahong 4; Fu, Ye ; Hu, Jianjun ; Chen, Yuanling 4; Liu, Linjing 4; Chen, Da Chun 3; Xiu, Mei Hong 3; Kosten, Thomas R.2; He, Jincai1
发表日期	2012-01-10
发表期刊	PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 影响因子和分区
语种	英语
原始文献类型	Review
关键词	Free radical Oxidative stress Psychopathology Schizophrenia Superoxide dismutase
其他关键词	ANTIOXIDANT DEFENSE SYSTEM ; ACID REACTIVE SUBSTANCES ; FREE-RADICAL PATHOLOGY ; TARDIVE-DYSKINESIA ; LIPID-PEROXIDATION ; OXIDATIVE STRESS ; ENZYME-ACTIVITIES ; THERAPEUTIC IMPLICATIONS ; ATYPICAL ANTIPSYCHOTICS ; GLUTATHIONE-PEROXIDASE
摘要	Excessive free radical production or oxidative stress may be involved in the pathophysiology of schizophrenia as evidenced by increased superoxide dismutase (SOD) activities, a critical enzyme in the detoxification of superoxide radicals. This study compared plasma SOD activities in 78 never-medicated first-episode and 100 medicated chronic schizophrenia patients to 100 healthy control subjects and correlated these SOD activities with the Positive and Negative Syndrome Scale (PANSS) among the schizophrenic patients. We found that both first-episode and chronic patients had significantly increased plasma SOD activities compared to controls, and that chronic schizophrenic patients on antipsychotic medication had significantly higher SOD activities than first episode schizophrenic patients. Plasma SOD activities were also negatively correlated with positive symptoms of schizophrenia, but only in first-episode patients. Thus, oxidative stress appears to be greater in first episode schizophrenic patients with fewer positive symptoms and may become greater as schizophrenia becomes more chronic, although we cannot exclude the possibility that chronic antipsychotic treatment may increase SOD activities and presumed oxidative stress in schizophrenia. (C) 2011 Elsevier Inc. All rights reserved.
资助项目	Stanley Medical Research Institute [03T-459, 05T-726]; Department of Veterans AffairsUS Department of Veterans Affairs; VISN 16; Mental Illness Research Education and Clinical Center (MIRECC); United States National Institute of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [K05-DA0454, P50-DA18827, U01-MH79639]; NATIONAL INSTITUTE OF MENTAL HEALTHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Mental Health (NIMH) [U01MH079639] Funding Source: NIH RePORTER; NATIONAL INSTITUTE ON DRUG ABUSEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Drug Abuse (NIDA)European Commission [K05DA000454] Funding Source: NIH RePORTER
出版者	PERGAMON-ELSEVIER SCIENCE LTD
出版地	OXFORD
ISSN	0278-5846
EISSN	1878-4216
卷号	36 期号:1 页码:34-38
DOI	10.1016/j.pnpbp.2011.08.018
页数	5
WOS类目	Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS研究方向	Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS记录号	WOS:000300073000007
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	21896300
SCOPUSEID	2-s2.0-82555190944
通讯作者地址	[Zhang, Xiang Yang]VA Med Ctr, Res Bldg 110,2002 Holcombe Blvd, Houston, TX 77030 USA.
引用统计	被引频次：41[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/11159
专题	附属第一医院_睡眠医学中心
通讯作者	Zhang, Xiang Yang
作者单位	1.Wenzhou Med Coll, Affiliated Hosp 1, Sleep Ctr, Wenzhou 325000, Peoples R China; 2.Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA; 3.Beijing Huilongguan Hosp, Ctr Psychiat Res, Beijing, Peoples R China; 4.Kangning Hosp, Dept Psychiat, Wenzhou, Peoples R China
推荐引用方式 GB/T 7714	Wu, Zhiwei,Zhang, Xiang Yang,Wang, Huanhuan,et al. Elevated plasma superoxide dismutase in first-episode and drug naive patients with schizophrenia: Inverse association with positive symptoms[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2012,36(1):34-38.
APA	Wu, Zhiwei., Zhang, Xiang Yang., Wang, Huanhuan., Tang, Wei., Xia, Yu., ... & He, Jincai. (2012). Elevated plasma superoxide dismutase in first-episode and drug naive patients with schizophrenia: Inverse association with positive symptoms. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 36(1), 34-38.
MLA	Wu, Zhiwei,et al."Elevated plasma superoxide dismutase in first-episode and drug naive patients with schizophrenia: Inverse association with positive symptoms".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 36.1(2012):34-38.