Resveratrol Improves Brain-Gut Axis by Regulation of 5-HT-Dependent Signaling in the Rat Model of Irritable Bowel Syndrome

doi:10.3389/fncel.2019.00030

科研成果详情

题名	Resveratrol Improves Brain-Gut Axis by Regulation of 5-HT-Dependent Signaling in the Rat Model of Irritable Bowel Syndrome
作者	Yu, Ying-Cong1,2; Li, Jing 3; Zhang, Meixi 4; Pan, Jian-Chun5; Yu, Ying 1; Zhang, Jian-Bo 5; Zheng, Liang 1; Si, Jian-Min 2; Xu, Ying 6
发表日期	2019-02-08
发表期刊	FRONTIERS IN CELLULAR NEUROSCIENCE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	irritable bowel syndrome chronic acute combining stress pCREB BDNF 5-HT
其他关键词	VISCERAL HYPERSENSITIVITY ; TRANS-RESVERATROL ; ADENYLYL-CYCLASE ; COLON IRRITATION ; INVOLVEMENT ; DEPRESSION
摘要	Irritable bowel syndrome (IBS) is at high risk of co-morbid depression and anxiety, which reduces patients' quality of life and increases the burden of health care costs. However, the pathophysiological mechanisms responsible for IBS still remain unknown. This study investigated the effects of resveratrol on stress-related depression, anxiety, intestinal and visceral dysfunction in rat model of IBS. Rats received chronic acute combining stress (CACS) for 22 days exhibited depression/anxiety-like behavior, visceral hypersensitivity and altered intestinal motility, as measured by the forced swimming, marble bury, abdominal withdrawal reflex (AWR) and intestinal tract motility (ITM) tests. These abnormalities were accompanied by reduced 5-hydroxytryptamine (5-HT) level in the hippocampus and increased 5-HT expression in the gut (ileum and colon) after CACS. Chronic treatment of IBS rats with resveratrol dose-dependently normalized CACS-induced both central nervous and peripheral dysfunction, which were consistent with its differentially regulating 5-HT contents in the brain and intestine. Pretreatment with the 5-HT1A receptor antagonist NAN-190 hydrobromide (NAN-190) prevented such effects. While sub-threshold of 5-HT1A receptor agonist 8-OH-DPAT potentiated the effects of low dose of resveratrol (10 mg/kg) on CACS-related behavioral abnormalities. Furthermore, resveratrol markedly increased PKA, p-cAMP-response element binding protein (p-CREB) and brain derived neurotrophic factor (BDNF) expression in the hippocampus of IBS rats, while decreased PKA, pCREB and BDNF levels were found in the ileum and colon. These effects were prevented by NAN-190, which were consistent with the behavioral changes. The present results suggested that resveratrol improved anti-IBS-like effects on depression, anxiety, visceral hypersensitivity and intestinal motility abnormality through regulating 5-HT1A-dependent PKA-CREB-BDNF signaling in the brain-gut axis.
资助项目	National Natural Science Foundation for the YouthNational Natural Science Foundation of China (NSFC) [NSFY 81400600]; Foundation from Wenzhou Science and Technology Bureau [H20150004]; Zhejiang Province Key Science and Technology Innovation Team [2013TD13]
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
ISSN	1662-5102
卷号	13 页码:30
DOI	10.3389/fncel.2019.00030
页数	10
WOS类目	Neurosciences
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:000458288300001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	30800058
PMC记录号	PMC6375832
SCOPUSEID	2-s2.0-85064220552
通讯作者地址	[Yu, Ying-Cong]Department of Gastroenterology,Wenzhou No. 3 Clinical Institute Affiliated to Wenzhou Medical University,Wenzhou People’s Hospital,Wenzhou,China
Scopus学科分类	Cellular and Molecular Neuroscience
引用统计	被引频次：33[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/11111
专题	温州医科大学药学院（分析测试中心）
通讯作者	Yu, Ying-Cong
作者单位	1.Department of Gastroenterology,Wenzhou No. 3 Clinical Institute Affiliated to Wenzhou Medical University,Wenzhou People’s Hospital,Wenzhou,China; 2.Institute of Gastroenterology,Zhejiang University,Hangzhou,China; 3.Department of Pharmacy,The Affiliated Hospital of Qingdao University,Qingdao,China; 4.Pingyang Hospital of Traditional Chinese Medicine,Pingyang,China; 5.Brain Institute,School of Pharmacy,Wenzhou Medical University,Wenzhou,China; 6.Department of Pharmaceutical Sciences,School of Pharmacy and Pharmaceutical Sciences,University at Buffalo,The State University of New York,Buffalo,United States
第一作者单位	温州医科大学
通讯作者单位	温州医科大学
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Yu, Ying-Cong,Li, Jing,Zhang, Meixi,et al. Resveratrol Improves Brain-Gut Axis by Regulation of 5-HT-Dependent Signaling in the Rat Model of Irritable Bowel Syndrome[J]. FRONTIERS IN CELLULAR NEUROSCIENCE,2019,13:30.
APA	Yu, Ying-Cong., Li, Jing., Zhang, Meixi., Pan, Jian-Chun., Yu, Ying., ... & Xu, Ying. (2019). Resveratrol Improves Brain-Gut Axis by Regulation of 5-HT-Dependent Signaling in the Rat Model of Irritable Bowel Syndrome. FRONTIERS IN CELLULAR NEUROSCIENCE, 13, 30.
MLA	Yu, Ying-Cong,et al."Resveratrol Improves Brain-Gut Axis by Regulation of 5-HT-Dependent Signaling in the Rat Model of Irritable Bowel Syndrome".FRONTIERS IN CELLULAR NEUROSCIENCE 13(2019):30.