Metabolomic analysis of exosomal-markers in esophageal squamous cell carcinoma

doi:10.1039/d1nr04015d

科研成果详情

题名	Metabolomic analysis of exosomal-markers in esophageal squamous cell carcinoma
作者	Zhu, Qingfu1; Huang, Liu 2; Yang, Qinsi 3; Ao, Zheng 4; Yang, Rui1; Krzesniak, Jonathan 4; Lou, Doudou1; Hu, Liang1; Dai, Xiaodan1; Guo, Feng 4; Liu, Fei1,3
发表日期	2021-10-14
发表期刊	NANOSCALE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Diagnosis Diseases Fatty acids Metabolites Amino-acids Cancer diagnosis Esophageal squamous cell carcinoma Exosomes Isobutyl Metabolomes Metabolomic analysis Metabolomics Mortality rate Palmitoleic acid
其他关键词	DIAGNOSIS ; CANCER
摘要	Esophageal squamous cell carcinoma (ESCC) is a worldwide malignancy with high mortality rates and poor prognosis due to the lack of effective biomarkers for early detection. Exosomes have been extensively explored as attractive biomarkers for cancer diagnosis and treatment. However, little is known about exosome metabolomics and their roles in ESCC. Here, we performed a targeted metabolomic analysis of plasma exosomes and identified 196 metabolites, mainly including lipid fatty acids, benzene, amino acids, organic acids, carbohydrates and fatty acyls. We systematically compared metabolome patterns of exosomes via machine learning from patients with recrudescence and patients without recrudescence and demonstrated a marker set consisting of 3 '-UMP, palmitoleic acid, palmitaldehyde, and isobutyl decanoate for predicting ESCC recurrence with an AUC of 98%. These metabolome signatures of exosomes retained a high absolute fold change value at all ESCC stages and were very likely associated with cancer metabolism, which could be potentially applied as novel biomarkers for diagnosis and prognosis of ESCC.
资助项目	Wenzhou Basic Research Projects [Y2020916]; Zhenan Technology City Research Fund; Wenzhou Medical University [89218012]; Wenzhou Institute, University of Chinese Academy of Sciences [WIBEZD2017006-05]; Zhejiang Provincial Natural Science FoundationNatural Science Foundation of Zhejiang Province [LQ18H120006]
出版者	ROYAL SOC CHEMISTRY
出版地	CAMBRIDGE
ISSN	2040-3364
EISSN	2040-3372
卷号	13 期号:39 页码:16457-16464
DOI	10.1039/d1nr04015d
页数	33
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS记录号	WOS:000689015800001
收录类别	SCIE ; PUBMED ; EI ; SCOPUS
EI入藏号	20214311044957
EI主题词	Biomarkers
URL	查看原文
PubMed ID	34648610
SCOPUSEID	2-s2.0-85117310645
通讯作者地址	[Liu, Fei]Eye Hospital,School of Ophthalmology and Optometry,School of Biomedical Engineering,Wenzhou Medical University,Zhejiang,Wenzhou,China ; [Guo, Feng]Department of Intelligent Systems Engineering,Indiana University,Bloomington,47405,United States
Scopus学科分类	Materials Science (all)
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/11095
专题	温州医科大学
通讯作者	Guo, Feng; Liu, Fei
作者单位	1.Eye Hospital,School of Ophthalmology and Optometry,School of Biomedical Engineering,Wenzhou Medical University,Zhejiang,Wenzhou,China; 2.Department of Laboratory Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China; 3.Wenzhou Institute,University of Chinese Academy of Sciences,Zhejiang,Wenzhou,China; 4.Department of Intelligent Systems Engineering,Indiana University,Bloomington,47405,United States
推荐引用方式 GB/T 7714	Zhu, Qingfu,Huang, Liu,Yang, Qinsi,et al. Metabolomic analysis of exosomal-markers in esophageal squamous cell carcinoma[J]. NANOSCALE,2021,13(39):16457-16464.
APA	Zhu, Qingfu., Huang, Liu., Yang, Qinsi., Ao, Zheng., Yang, Rui., ... & Liu, Fei. (2021). Metabolomic analysis of exosomal-markers in esophageal squamous cell carcinoma. NANOSCALE, 13(39), 16457-16464.
MLA	Zhu, Qingfu,et al."Metabolomic analysis of exosomal-markers in esophageal squamous cell carcinoma".NANOSCALE 13.39(2021):16457-16464.