BL153 Partially Prevents High-Fat Diet Induced Liver Damage Probably via Inhibition of Lipid Accumulation, Inflammation, and Oxidative Stress

doi:10.1155/2014/674690

科研成果详情

题名	BL153 Partially Prevents High-Fat Diet Induced Liver Damage Probably via Inhibition of Lipid Accumulation, Inflammation, and Oxidative Stress
作者	Wang, Jian 1,2,3; Zhang, Chi 2,4; Zhang, Zhiguo 3,5; Chen, Qiang 3,5; Lu, Xuemian2,4; Shao, Minglong2,4; Chen, Liangmiao2,4; Yang, Hong2,4; Zhang, Fangfang 2,4; Cheng, Peng 2,4; Tan, Yi2,3; Kim, Ki-Soo 6; Kim, Ki Ho 7; Wang, Bochu 1; Kim, Young Heui 7
发表日期	2014-12-31
发表期刊	OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Anthropometry Collagen Musculoskeletal system Oxidative stress Pathology Age-matched controls Connective tissue growth factor Critical steps Dose-dependent manner Hepatic fibrosis Lipid accumulations Mechanism studies Transforming growth factor beta
其他关键词	EXTRACELLULAR-MATRIX ; INDUCED APOPTOSIS ; RENAL FIBROSIS ; HONOKIOL ; DISEASE ; MAGNOLOL ; OBESITY ; EPIDEMIOLOGY ; PEROXIDATION ; SUPPRESSION
摘要	The present study was to investigate whether a magnolia extract, named BL153, can prevent obesity-induced liver damage and identify the possible protective mechanism. To this end, obese mice were induced by feeding with high fat diet (HFD, 60% kcal as fat) and the age-matched control mice were fed with control diet (10% kcal as fat) for 6 months. Simultaneously these mice were treated with or without BL153 daily at 3 dose levels (2.5, 5, and 10mg/kg) by gavage. HFD feeding significantly increased the body weight and the liver weight. Administration of BL153 significantly reduced the liver weight but without effects on body weight. As a critical step of the development of NAFLD, hepatic fibrosis was induced in the mice fed with HFD, shown by upregulating the expression of connective tissue growth factor and transforming growth factor beta 1, which were significantly attenuated by BL153 in a dose-dependent manner. Mechanism study revealed that BL153 significantly suppressed HFD induced hepatic lipid accumulation and oxidative stress and slightly prevented liver inflammation. These results suggest that HFD induced fibrosis in the liver can be prevented partially by BL153, probably due to reduction of hepatic lipid accumulation, inflammation and oxidative stress.
资助项目	Chungbuk Technopark Grant Biointernational Collaborating Research; Chungbuk Province, Republic of Korea; University of Louisville; BioLand Co., Ltd. [100826 Bioland]; National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81000294, 81370917]; Research Development Fund of Wenzhou Medical University [QTJ13005, QTJ 13007]
出版者	HINDAWI LTD
出版地	LONDON
ISSN	1942-0900
EISSN	1942-0994
卷号	2014 页码:674690
DOI	10.1155/2014/674690
页数	51
WOS类目	Cell Biology
WOS研究方向	Cell Biology
WOS记录号	WOS:000334248100001
收录类别	SCIE ; PUBMED ; EI ; SCOPUS
EI入藏号	20141917689371
EI主题词	Mammals
URL	查看原文
PubMed ID	24803983
PMC记录号	PMC3997087
SCOPUSEID	2-s2.0-84899578421
通讯作者地址	[Wang, Bochu]College of Bioengineering, Chongqing University,China
Scopus学科分类	Biochemistry;Aging;Cell Biology
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/11059
专题	药学院（分析测试中心）其他_附属第三医院（瑞安市人民医院）药学院（分析测试中心）_生物制药系_生物制药工程
通讯作者	Wang, Bochu
作者单位	1.College of Bioengineering, Chongqing University,China; 2.Chinese-American Research Institute for Diabetic Complications, School of Pharmaceutical Sciences, Wenzhou Medical University,China; 3.Department of Pediatrics, University of Louisville, Kosair Children's Hospital Research Institute,United States; 4.Rui'An Center of the Chinese-American Research Institute for Diabetic Complications, Third Affiliated Hospital of the Wenzhou Medical University,China; 5.Department of Cardiology at the First Hospital and School of Public Health, Jilin University,China; 6.Bioland Biotec Co., Ltd., Zhangjiang Modern Medical Device Park,China; 7.Bioland RandD Center,59 Songjeongni 2-gil,South Korea
第一作者单位	药学院（分析测试中心）
推荐引用方式 GB/T 7714	Wang, Jian,Zhang, Chi,Zhang, Zhiguo,et al. BL153 Partially Prevents High-Fat Diet Induced Liver Damage Probably via Inhibition of Lipid Accumulation, Inflammation, and Oxidative Stress[J]. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,2014,2014:674690.
APA	Wang, Jian., Zhang, Chi., Zhang, Zhiguo., Chen, Qiang., Lu, Xuemian., ... & Kim, Young Heui. (2014). BL153 Partially Prevents High-Fat Diet Induced Liver Damage Probably via Inhibition of Lipid Accumulation, Inflammation, and Oxidative Stress. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2014, 674690.
MLA	Wang, Jian,et al."BL153 Partially Prevents High-Fat Diet Induced Liver Damage Probably via Inhibition of Lipid Accumulation, Inflammation, and Oxidative Stress".OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2014(2014):674690.