Bioallethrin activates specific olfactory sensory neurons and elicits spatial repellency in Aedes aegypti

doi:10.1002/ps.6682

科研成果详情

题名	Bioallethrin activates specific olfactory sensory neurons and elicits spatial repellency in Aedes aegypti
作者	Valbon, Wilson 1,2,3; Andreazza, Felipe 1,2,3; Oliveira, Eugenio E 1,2; Liu, Feng 1; Feng, Bo 1,4; Hall, Maura 5; Klimavicz, James 5; Coats, Joel R 5; Dong, Ke 1,3
发表日期	2022-02
发表期刊	PEST MANAGEMENT SCIENCE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	pyrethroids spatial repellency olfaction sodium channels
其他关键词	PYRETHROID RESISTANCE ; COMPARATIVE EFFICACY ; DIPTERA-CULICIDAE ; SODIUM-CHANNELS ; MOSQUITOS ; ALLETHRIN ; MECHANISMS ; COILS ; P450S
摘要	BACKGROUND Use of pyrethroid insecticides is a pivotal strategy for mosquito control globally. Commonly known for their insecticidal activity by acting on voltage-gated sodium channels, pyrethroids, such as bioallethrin and transfluthrin, are used in mosquito coils, emanators and other vaporizers to repel mosquitoes and other biting arthropods. However, whether specific olfactory receptor neurons are activated by pyrethroids to trigger spatial repellency remains unknown. RESULTS We used behavioral and electrophysiological approaches to elucidate the mechanism of bioallethrin repellency in Aedes aegypti, a major vector of dengue, yellow fever, Zika and chikungunya viruses. We found that bioallethrin elicits spatial (i.e. non-contact) repellency and activates a specific type of olfactory receptor neuron in mosquito antennae. Furthermore, bioallethrin repellency is significantly reduced in a mosquito mutant of Orco, an obligate olfactory co-receptor that is essential for the function of odorant receptors (Ors). These results indicate that activation of specific Or(s) by bioallethrin contributes to bioallethrin repellency. In addition, bioallethrin repellency was reduced in a pyrethroid-resistant strain that carries two mutations in the sodium channel gene that are responsible for knockdown resistance (kdr) to pyrethroids, indicating a role of activation of sodium channels in bioallethrin repellency. CONCLUSION Results from this study show that bioallethrin repellency is likely to be the result of co-activation of Or(s) and sodium channels. These findings not only contribute to our understanding of the modes of action of volatile pyrethroids in spatial repellency, but also provide a framework for developing new repellents based on the dual-target mechanism revealed.
资助项目	National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [GM115475, GM057440]; Iowa Agricultural Experiment Station, Ames, Iowa; CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior) FoundationCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [001]; CAPES-PrInt [8887.311952/2018-00]
出版者	JOHN WILEY & SONS LTD
出版地	CHICHESTER
ISSN	1526-498X
EISSN	1526-4998
卷号	78 期号:2 页码:438-445
DOI	10.1002/ps.6682
页数	8
WOS类目	Agronomy ; Entomology
WOS研究方向	Agriculture ; Entomology
WOS记录号	WOS:000711500400001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	34661374
PMC记录号	PMC8748403
SCOPUSEID	2-s2.0-85118220567
通讯作者地址	[Dong, Ke]Department of Entomology,Michigan State University,East Lansing,United States
Scopus学科分类	Agronomy and Crop Science;Insect Science
TOP期刊	TOP期刊
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/11021
专题	公共卫生学院_健康与环境生态研究所
通讯作者	Dong, Ke
作者单位	1.Department of Entomology,Michigan State University,East Lansing,United States; 2.Department of Entomology,Universidade Federal de Viçosa,Viçosa,Brazil; 3.Department of Biology,Duke University,Durham,United States; 4.Institute of Health and Environment,Wenzhou Medical University,Wenzhou,China; 5.Department of Entomology,Iowa State University,Ames,United States
推荐引用方式 GB/T 7714	Valbon, Wilson,Andreazza, Felipe,Oliveira, Eugenio E,et al. Bioallethrin activates specific olfactory sensory neurons and elicits spatial repellency in Aedes aegypti[J]. PEST MANAGEMENT SCIENCE,2022,78(2):438-445.
APA	Valbon, Wilson., Andreazza, Felipe., Oliveira, Eugenio E., Liu, Feng., Feng, Bo., ... & Dong, Ke. (2022). Bioallethrin activates specific olfactory sensory neurons and elicits spatial repellency in Aedes aegypti. PEST MANAGEMENT SCIENCE, 78(2), 438-445.
MLA	Valbon, Wilson,et al."Bioallethrin activates specific olfactory sensory neurons and elicits spatial repellency in Aedes aegypti".PEST MANAGEMENT SCIENCE 78.2(2022):438-445.