Association of Matrix Metalloproteinase-1 and Matrix Metalloproteinase-3 Gene Variants with Ischemic Stroke and Its Subtype

doi:10.1016/j.jstrokecerebrovasdis.2016.09.034

科研成果详情

题名	Association of Matrix Metalloproteinase-1 and Matrix Metalloproteinase-3 Gene Variants with Ischemic Stroke and Its Subtype
作者	Huang, Xiao-Ya1; Han, Li-Ya 1; Huang, Xiang-Dong1; Guan, Chao-Hong 1; Mao, Xin-Lei 1; Ye, Zu-Sen2
发表日期	2017-02
发表期刊	JOURNAL OF STROKE & CEREBROVASCULAR DISEASES 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Ischemic stroke matrix metalloproteinase polymorphism stroke subtype
其他关键词	RAPID GENOTYPE ANALYSIS ; CAROTID ATHEROSCLEROSIS ; 5A/6A POLYMORPHISM ; PROMOTER ; CORONARY ; RISK ; DISEASE ; SUSCEPTIBILITY ; POPULATION ; EXPRESSION
摘要	Background: Genetic variations in the genes of matrix metalloproteinases (MMPs) may play an important role in the pathogenesis of ischemic stroke (IS). Here we investigate the association between MMP-1 -1607 1G/2G and MMP-3 -1171 5A/ 6A genetic polymorphisms and etiological subtypes of IS in the Han Chinese population. Methods: A total of 640 eligible patients with IS and 637 age-and gender-matched apparently healthy volunteers were enrolled. Subtypes of IS were classified by Trial of Org 10172 in Acute Stroke Treatment criteria. MMP-1 (-1607 1G/2G) and MMP-3 (-1171 5A/6A) polymorphisms were evaluated using polymerase chain reaction-restriction fragment length polymorphism. Results: The frequencies of the 5A/6A + 5A/5A genotypes and 5A allele were significantly higher in patients with IS than in controls (P <.001, P <.001, respectively). No association was found between MMP-1 1G/2G polymorphism and overall IS. In subgroup analyses, MMP-1 1G/2G and 2G/2G genotypes increased the risk of small-artery occlusion (SAO) subtype (multivariate-adjusted, P <.001, P =.002, respectively), and MMP-3 5A/6A + 5A/5A genotypes were related with largeartery atherosclerosis (LAA) subtype (multivariate-adjusted, P <.001). Haplotype analyses indicated that 2G-6A and 1G-5A increased the risk of SAO (multivariateadjusted, P =.029) and LAA (multivariate-adjusted, P <.001), respectively. Conclusions: MMP-1 (-1607 1G/2G) and MMP-3 (-1171 5A/6A) polymorphisms may contribute to different subtypes of IS susceptibility.
资助项目	Wenzhou Health Bureau (The Double Eagle Plan) [2013-334]; Wenzhou Municipal Science and Technology Bureau [2015Y0140]
出版者	ELSEVIER SCIENCE BV
出版地	AMSTERDAM
ISSN	1052-3057
EISSN	1532-8511
卷号	26 期号:2 页码:368-375
DOI	10.1016/j.jstrokecerebrovasdis.2016.09.034
页数	8
WOS类目	Neurosciences ; Peripheral Vascular Disease
WOS研究方向	Neurosciences & Neurology ; Cardiovascular System & Cardiology
WOS记录号	WOS:000397253200022
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	27793533
SCOPUSEID	2-s2.0-85005973830
通讯作者地址	[Ye, Zu-Sen]Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,No. 2 Fuxue Lane,Wenzhou,325000,China
Scopus学科分类	Surgery;Rehabilitation;Neurology (clinical);Cardiology and Cardiovascular Medicine
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/1094
专题	第二临床医学院、附属第二医院、育英儿童医院_神经病学附属第一医院其他_定理临床学院（温州市中心医院）第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
通讯作者	Ye, Zu-Sen
作者单位	1.Department of Neurology,Wenzhou Central Hospital & Dingli Clinical Institute of Wenzhou Medical University,Wenzhou,325000,China; 2.Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
第一作者单位	温州医科大学
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Huang, Xiao-Ya,Han, Li-Ya,Huang, Xiang-Dong,et al. Association of Matrix Metalloproteinase-1 and Matrix Metalloproteinase-3 Gene Variants with Ischemic Stroke and Its Subtype[J]. JOURNAL OF STROKE & CEREBROVASCULAR DISEASES,2017,26(2):368-375.
APA	Huang, Xiao-Ya, Han, Li-Ya, Huang, Xiang-Dong, Guan, Chao-Hong, Mao, Xin-Lei, & Ye, Zu-Sen. (2017). Association of Matrix Metalloproteinase-1 and Matrix Metalloproteinase-3 Gene Variants with Ischemic Stroke and Its Subtype. JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 26(2), 368-375.
MLA	Huang, Xiao-Ya,et al."Association of Matrix Metalloproteinase-1 and Matrix Metalloproteinase-3 Gene Variants with Ischemic Stroke and Its Subtype".JOURNAL OF STROKE & CEREBROVASCULAR DISEASES 26.2(2017):368-375.