Zinc treatment prevents type 1 diabetes-induced hepatic oxidative damage, endoplasmic reticulum stress, and cell death, and even prevents possible steatohepatitis in the OVE26 mouse model: Important role of metallothionein

doi:10.1016/j.toxlet.2015.01.010

科研成果详情

题名	Zinc treatment prevents type 1 diabetes-induced hepatic oxidative damage, endoplasmic reticulum stress, and cell death, and even prevents possible steatohepatitis in the OVE26 mouse model: Important role of metallothionein
作者	Liang, Tingting 1,2,3; Zhang, Quan 1,3; Sun, Weixia 2,4; Xin, Ying 2,5; Zhang, Zhiguo 3,4; Tan, Yi2,3; Zhou, Shanshan 3,4; Zhang, Chi 2; Cai, Lu2,3; Lu, Xuemian2; Cheng, Mingliang 1
发表日期	2015-03-04
发表期刊	TOXICOLOGY LETTERS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Hepatic dysfunction Liver injury ER stress Metallothionein Diabetic complications Zinc
其他关键词	ALCOHOLIC LIVER-INJURY ; FATTY LIVER ; MICE ; SUPPLEMENTATION ; DISEASE ; MELLITUS ; CARDIOMYOPATHY ; RATS ; ACTIVATION ; INDUCTION
摘要	Whether zinc is able to improve diabetes-induced liver injury remains unknown. Transgenic type 1 diabetic (OVE26) mice develop hyperglycemia at 3 weeks old; therefore therapeutic effect of zinc on diabetes-induced liver injury was investigated in OVE26 mice. Three-month old OVE26 and age-matched wild-type mice were treated by gavage with saline or zinc at 5 mg/kg body-weight every other day for 3 months. Hepatic injury was examined by serum alanine aminotransferase (ALT) level with liver histopathological and biochemical changes. OVE26 mice at 6 months old showed significant increases in serum ALT level and hepatic oxidative damage, endoplasmic reticulum stress and associated cell death, mild inflammation, and fibrosis. However, all these hepatic morphological and functional changes were significantly prevented in 3-month zinc-treated OVE26 mice. Mechanistically, zinc treatment significantly increased hepatic metallothionein, a protein with known antioxidant activity, in both wild-type and OVE26 mice. These results suggest that there were significantly functional, structural and biochemical abnormalities in the liver of OVE26 diabetic mice at 6 months old; however, all these changes could be prevented with zinc treatment, which was associated with the upregulation of hepatic metallothionein expression. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
资助项目	Natural Science foundation of Guizhou Educational Department [2011037]
出版者	ELSEVIER IRELAND LTD
出版地	CLARE
ISSN	0378-4274
EISSN	1879-3169
卷号	233 期号:2 页码:114-124
DOI	10.1016/j.toxlet.2015.01.010
页数	11
WOS类目	Toxicology
WOS研究方向	Toxicology
WOS记录号	WOS:000349631300007
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	25617602
SCOPUSEID	2-s2.0-84961291031
通讯作者地址	[Cai, Lu]Kosair Children's Hospital Research Institute,570 South Preston Street, Baxter I Building,Louisville,40292,United States
Scopus学科分类	Toxicology
引用统计	被引频次：40[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/10842
专题	其他_附属第三医院（瑞安市人民医院）
通讯作者	Cai, Lu
作者单位	1.Department of Infectious Diseases,Affiliated Hospital of Guiyang Medical College,Guiyang,Guizhou,550004,China; 2.The RuiAn Center of Chinese-American Research Institute for Diabetic Complications,Dept of Endocrinology of The Third Affiliated Hospital of Wenzhou Medical University,RuiAn, Zhejiang,325200,China; 3.Kosair Children's Hospital Research Institute,The Department of Pediatrics of the University of Louisville,Louisville,40202,United States; 4.The First Hospital of Jilin University,Changchun, Jilin,130021,China; 5.The Key Laboratory of Pathobiology of Ministry of Education,The Norman Bethune Medical College of Jilin Univ.,Changchun, Jilin,130021,China
第一作者单位	其他_附属第三医院（瑞安市人民医院）
推荐引用方式 GB/T 7714	Liang, Tingting,Zhang, Quan,Sun, Weixia,et al. Zinc treatment prevents type 1 diabetes-induced hepatic oxidative damage, endoplasmic reticulum stress, and cell death, and even prevents possible steatohepatitis in the OVE26 mouse model: Important role of metallothionein[J]. TOXICOLOGY LETTERS,2015,233(2):114-124.
APA	Liang, Tingting., Zhang, Quan., Sun, Weixia., Xin, Ying., Zhang, Zhiguo., ... & Cheng, Mingliang. (2015). Zinc treatment prevents type 1 diabetes-induced hepatic oxidative damage, endoplasmic reticulum stress, and cell death, and even prevents possible steatohepatitis in the OVE26 mouse model: Important role of metallothionein. TOXICOLOGY LETTERS, 233(2), 114-124.
MLA	Liang, Tingting,et al."Zinc treatment prevents type 1 diabetes-induced hepatic oxidative damage, endoplasmic reticulum stress, and cell death, and even prevents possible steatohepatitis in the OVE26 mouse model: Important role of metallothionein".TOXICOLOGY LETTERS 233.2(2015):114-124.