Neurodevelopmental toxicity assessments of alkyl phenanthrene and Dechlorane Plus co-exposure in zebrafish

doi:10.1016/j.ecoenv.2019.05.066

科研成果详情

题名	Neurodevelopmental toxicity assessments of alkyl phenanthrene and Dechlorane Plus co-exposure in zebrafish
作者	Chen, Xiangping 1,2; Chen, Yuanhong3; Huang, Changjiang 3; Dong, Qiaoxiang3,4; Roper, Courtney 5; Tanguay, Rorbet L.5; Zhu, Yaxian 6; Zhang, Yong 1
发表日期	2019-09-30
发表期刊	ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Alkyl phenanthrene Dechlorane plus Co-exposure Neurodevelopmental toxicity Synergistic effect
其他关键词	AXONAL GROWTH ; MOTOR BEHAVIOR ; DECABROMODIPHENYL ETHER ; EXPOSURE ; PAHS ; PRECIPITATION ; CHLORPYRIFOS ; MUSCULATURE ; RESPONSES ; MIXTURES
摘要	Alkyl phenanthrene (A-Phen) and Dechlorane Plus (DP) are ubiquitous environmental pollutants that widely coexist in the environment. It has been established that both A-Phen and DP elicit neurotoxicity, but the potential interactive toxicity of these contaminants is not well-known. To determine whether a mixture of A-Phen and DP would exhibit interactive effects on neurodevelopment, we co-exposed 3-methylphenanthrene (3-MP), a representative of A-Phen, with DP. Our results illustrated that exposure to 5 or 20 mu g/L 3-MP alone or in combination with 60 mu g/L DP caused neurobehavioral anomalies in zebrafish. In accordance with the behavioral deficits, 3-MP alone or co-exposed with DP significantly decreased axonal growth of secondary motoneurons, altered intracellular Ca2+ homeostasis and induced cell apoptosis in the muscle of zebrafish. Additionally, 3-MP alone or co-exposed with DP significantly increased reactive oxygen species (ROS) and the mRNA levels of apoptosis-related genes. These findings indicate that 3-MP alone or co-exposed with DP induces neurobehavioral deficits through the combined effects on neuronal connectivity and muscle function. Chemical analysis revealed significant increases in 3-MP and DP bioaccumulation in zebrafish co-exposed with 3-MP and DP. Elevated bioaccumulation resulting from mixture exposure may represent a significant contribution of the synergistic effects observed in combined chemical exposure.
资助项目	Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21577110, 21627814]; National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [T32 ES007060]
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
出版地	SAN DIEGO
ISSN	0147-6513
EISSN	1090-2414
卷号	180 页码:762-769
DOI	10.1016/j.ecoenv.2019.05.066
页数	8
WOS类目	Environmental Sciences ; Toxicology
WOS研究方向	Environmental Sciences & Ecology ; Toxicology
WOS记录号	WOS:000473836100086
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	31154201
SCOPUSEID	2-s2.0-85066239460
通讯作者地址	[Zhang, Yong]State Key Laboratory of Marine Environmental Science of China (Xiamen University),College of Environment and Ecology,Xiamen University,Xiamen,361102,China
Scopus学科分类	Pollution;Public Health, Environmental and Occupational Health;Health, Toxicology and Mutagenesis
TOP期刊	TOP期刊
引用统计	被引频次：14[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/10639
专题	公共卫生学院_健康与环境生态研究所附属第二医院第二临床医学院、附属第二医院、育英儿童医院公共卫生学院_环境安全与健康风险评估研究院
通讯作者	Zhang, Yong
作者单位	1.State Key Laboratory of Marine Environmental Science of China (Xiamen University),College of the Environment and Ecology,Xiamen University,Xiamen,361102,China; 2.State Key Laboratory of Freshwater Ecology and Biotechnology,Institute of Hydrobiology,Chinese Academy of Sciences,Wuhan,430072,China; 3.Institute of Environmental Safety and Human Health,Wenzhou Medical University,Wenzhou,325035,China; 4.The Second Affiliated Hospital and Yuying Children's Hospital,Wenzhou Medical University,Wenzhou,325035,China; 5.Environmental and Molecular Toxicology,The Sinnhuber Aquatic Research Laboratory and the Environmental Health Sciences Center,Oregon State University,Corvallis,97333,United States; 6.Department of Chemistry,College of Chemistry and Chemical Engineering,Xiamen University,Xiamen,361005,China
推荐引用方式 GB/T 7714	Chen, Xiangping,Chen, Yuanhong,Huang, Changjiang,et al. Neurodevelopmental toxicity assessments of alkyl phenanthrene and Dechlorane Plus co-exposure in zebrafish[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2019,180:762-769.
APA	Chen, Xiangping., Chen, Yuanhong., Huang, Changjiang., Dong, Qiaoxiang., Roper, Courtney., ... & Zhang, Yong. (2019). Neurodevelopmental toxicity assessments of alkyl phenanthrene and Dechlorane Plus co-exposure in zebrafish. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 180, 762-769.
MLA	Chen, Xiangping,et al."Neurodevelopmental toxicity assessments of alkyl phenanthrene and Dechlorane Plus co-exposure in zebrafish".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 180(2019):762-769.