Extracellular vesicles extracted from young donor serum attenuate inflammaging via partially rejuvenating aged T-cell immunotolerance

doi:10.1096/fj.201800059R

科研成果详情

题名	Extracellular vesicles extracted from young donor serum attenuate inflammaging via partially rejuvenating aged T-cell immunotolerance
作者	Wang, Weikan 1,2; Wang, Liefeng 1,3; Ruan, Linhui 1,2; Oh, Jiyoung 1; Dong, Xiaowei 4; Zhuge, Qichuan 2; Su, Dong-Ming 1
发表日期	2018-11
发表期刊	FASEB JOURNAL 影响因子和分区
语种	英语
原始文献类型	Article
关键词	young serum exosomes rejuvenation age-related thymic involution chronic inflammation
其他关键词	CENTRAL-NERVOUS-SYSTEM ; NEGATIVE SELECTION ; THYMIC INVOLUTION ; COGNITIVE FUNCTION ; IMMUNE-RESPONSES ; SKELETAL-MUSCLE ; MICRORNAS ; SENESCENCE ; BRAIN ; MOUSE
摘要	Biologic aging results in a chronic inflammatory condition, termed inflammaging, which establishes a risk for such age-related diseases as neurocardiovascular diseases; therefore, it is of great importance to develop rejuvenation strategies that are able to attenuate inflammaging as a means of intervention for age-related diseases. A promising rejuvenation factor that is present in young blood has been found that can make aged neurons younger; however, the component in the young blood and its mechanism of action are poorly elucidated. We assessed rejuvenation in naturally aged mice with extracellular vesicles (EVs) or exosomes extracted from young murine serum on the basis of different spectrums of microRNAs in these vesicles from young and old sera. We found that EVs extracted from young donor mouse serum, rather than EVs extracted from old donor mouse serum or non-EV supernatant extracted from young donor mouse serum, were able to attenuate inflammaging in old mice. Inflammaging is attributed to multiple factors, one of which is thymic aging-released self-reactive T cell-induced pathology. We found that the attenuation of inflammaging after treatment with EVs from young serum partially contributed to the rejuvenation of thymic aging, which is characterized by partially reversed thymic involution, enhancement of negative selection signals, and reduced autoreactions in the periphery. Our results provide evidence for understanding of the potential rejuvenation factor in the young donor serum, which holds great promise for the development of novel therapeutics to reduce morbidity and mortality caused by age-related inflammatory diseases.Wang, W., Wang, L., Ruan, L., Oh, J., Dong, X., Zhuge, Q., Su, D.-M. Extracellular vesicles extracted from young donor serum attenuate inflammaging via partially rejuvenating aged T-cell immunotolerance.
资助项目	U.S. National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases [R01-AI121147]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31660256]; NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Allergy & Infectious Diseases (NIAID) [R01AI121147] Funding Source: NIH RePORTER
出版者	FEDERATION AMER SOC EXP BIOL
出版地	BETHESDA
ISSN	0892-6638
EISSN	1530-6860
卷号	32 期号:11 页码:5899-5912
DOI	10.1096/fj.201800059R
页数	14
WOS类目	Biochemistry & Molecular Biology ; Biology ; Cell Biology
WOS研究方向	Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology
WOS记录号	WOS:000447172000012
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
Pubmed记录号	29782203
PMC记录号	PMC6181631
Scopus记录号	2-s2.0-85053110335
通讯作者地址	[Su, Dong-Ming]Department of Microbiology,Immunology,and Genetics,University of North Texas Health Science Center,3500 Camp Bowie Blvd.,Fort Worth,76107,United States
scopus学科分类	Biotechnology;Biochemistry;Molecular Biology;Genetics
引用统计	被引频次：32[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/10351
专题	第一临床医学院（信息与工程学院）、附属第一医院_老化与神经疾病重点实验室附属第一医院
通讯作者	Su, Dong-Ming
作者单位	1.Department of Microbiology,Immunology,and Genetics,University of North Texas Health Science Center,3500 Camp Bowie Blvd.,Fort Worth,76107,United States; 2.Department of Pharmaceutical Sciences,University of North Texas Health Science Center,Fort Worth,United States; 3.Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research,First Affiliated Hospital,Wenzhou Medical University,Wenzhou,China; 4.Department of Biotechnology,Gannan Medical University,Ganzhou,China
推荐引用方式 GB/T 7714	Wang, Weikan,Wang, Liefeng,Ruan, Linhui,et al. Extracellular vesicles extracted from young donor serum attenuate inflammaging via partially rejuvenating aged T-cell immunotolerance[J]. FASEB JOURNAL,2018,32(11):5899-5912.
APA	Wang, Weikan., Wang, Liefeng., Ruan, Linhui., Oh, Jiyoung., Dong, Xiaowei., ... & Su, Dong-Ming. (2018). Extracellular vesicles extracted from young donor serum attenuate inflammaging via partially rejuvenating aged T-cell immunotolerance. FASEB JOURNAL, 32(11), 5899-5912.
MLA	Wang, Weikan,et al."Extracellular vesicles extracted from young donor serum attenuate inflammaging via partially rejuvenating aged T-cell immunotolerance".FASEB JOURNAL 32.11(2018):5899-5912.