Microenvironment construction of strontium-calcium-based biomaterials for bone tissue regeneration: the equilibrium effect of calcium to strontium

doi:10.1039/c8tb00306h

科研成果详情

题名	Microenvironment construction of strontium-calcium-based biomaterials for bone tissue regeneration: the equilibrium effect of calcium to strontium
作者	Xie, Huixu 1,2,3; Gu, Zhipeng 4; He, Yan 3,5; Xu, Jia3; Xu, Chun 5; Li, Longjiang 1,2; Ye, Qingsong3,5
发表日期	2018-04-21
发表期刊	JOURNAL OF MATERIALS CHEMISTRY B 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Biomineralization Calcification (biochemistry) Calcium phosphate Ions Phosphatases Strontium compounds Tissue Tissue regeneration Alkaline phosphatase activity Beneficial effects Bone tissue regeneration Bone tissue substitutes Calcium concentration Doped calcium phosphates Equilibrium effects Experimental animals
其他关键词	IN-VITRO ; RANELATE ; SCAFFOLDS ; ANGIOGENESIS ; FRACTURE ; LEVEL ; ZINC
摘要	Strontium-doped calcium phosphate-based biomaterials have gained increased recognition due to their beneficial effects on bone formation. However, the underlying mechanism is still not clear. In this study, we detected the calcification effects of strontium-based materials on osteoblasts in vitro and bone formation in vivo. The results showed that strontium may inhibit bone cell function in osteoblasts under a standard calcium concentration (1.8 mM) by both reducing alkaline phosphatase activity and inhibiting absorption of osteopontin and osteocalcin. In contrast, a high calcium concentration (9 mM) enhances the bone regeneration effect of strontium-based materials. Cultured osteoblasts underwent increased proliferation, calcification and alkaline phosphatase activity upon increasing calcium concentrations. An experimental animal model was utilized to simulate a high calcium concentration microenvironment in bone tissue and low calcium concentration in the subcutaneous part and the in vivo results are similar to the in vitro results. These findings suggest that strontium only promoted an anabolic effect on osteoblasts to enhance osteogenesis in a calcium rich microenvironment. Strontium would inhibit bone regeneration under a low dose of calcium in vivo. Therefore, strontium seems to be a potentially effective therapeutic option for bone regeneration in combination with a high concentration environment of calcium ions. These results would provide an in-depth knowledge of an ion-based bone tissue substitute for bone regeneration.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51641305, 81701032]; youth fund of Sichuan University; Australia Research CouncilAustralian Research Council [DE120101666]; Sichuan UniversitySichuan University; West China School of Stomatology
出版者	ROYAL SOC CHEMISTRY
出版地	CAMBRIDGE
ISSN	2050-750X
EISSN	2050-7518
卷号	6 期号:15 页码:2332-2339
DOI	10.1039/c8tb00306h
页数	29
WOS类目	Materials Science, Biomaterials
WOS研究方向	Materials Science
WOS记录号	WOS:000431111700015
收录类别	SCIE ; EI ; SCOPUS
EI入藏号	20181705043739
EI主题词	Bone
URL	查看原文
PubMed ID	32254572
SCOPUSEID	2-s2.0-85045626711
通讯作者地址	[Li, Longjiang]State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,Sichuan University,Chengdu,610041,China
Scopus学科分类	Chemistry (all);Biomedical Engineering;Materials Science (all)
引用统计	被引频次：32[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/10244
专题	口腔医学院、附属口腔医院_干细胞与组织工程研究所
通讯作者	Li, Longjiang
作者单位	1.State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,Sichuan University,Chengdu,610041,China; 2.West China School of Stomatology,Sichuan University,Chengdu,610041,China; 3.JCU-WMU Joint Research Group of Tissue Engineering,School of Stomatology,Wenzhou Medical University,Wenzhou,325000,China; 4.Department of Biomedical Engineering,School of Engineering,Sun Yat-sen University,Guangzhou,510006,China; 5.Oral Health Centre,University of Queensland,Herston,4006,Australia
第一作者单位	口腔医学院、附属口腔医院
推荐引用方式 GB/T 7714	Xie, Huixu,Gu, Zhipeng,He, Yan,et al. Microenvironment construction of strontium-calcium-based biomaterials for bone tissue regeneration: the equilibrium effect of calcium to strontium[J]. JOURNAL OF MATERIALS CHEMISTRY B,2018,6(15):2332-2339.
APA	Xie, Huixu., Gu, Zhipeng., He, Yan., Xu, Jia., Xu, Chun., ... & Ye, Qingsong. (2018). Microenvironment construction of strontium-calcium-based biomaterials for bone tissue regeneration: the equilibrium effect of calcium to strontium. JOURNAL OF MATERIALS CHEMISTRY B, 6(15), 2332-2339.
MLA	Xie, Huixu,et al."Microenvironment construction of strontium-calcium-based biomaterials for bone tissue regeneration: the equilibrium effect of calcium to strontium".JOURNAL OF MATERIALS CHEMISTRY B 6.15(2018):2332-2339.