Cardiac hypertrophy limits infarct expansion after myocardial infarction in mice

doi:10.1038/s41598-018-24525-6

科研成果详情

题名	Cardiac hypertrophy limits infarct expansion after myocardial infarction in mice
作者	Iismaa, Siiri E.1,2; Li, Ming 1,3; Kesteven, Scott 1; Wu, Jianxin 1; Chan, Andrea Y.1; Holman, Sara R.1; Calvert, John W.5; Haq, Ahtesham Ul 1; Nicks, Amy M.1; Naqvi, Nawazish 4; Husain, Ahsan 4; Feneley, Michael P.1,2; Graham, Robert M.1,2
发表日期	2018-04-17
发表期刊	SCIENTIFIC REPORTS 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	RECRUITABLE STROKE WORK ; NEONATAL MOUSE HEART ; IN-VIVO ; CARDIOMYOPATHY ; QUANTIFICATION ; MUTATIONS ; FAILURE
摘要	We have previously demonstrated that adult transgenic C57BL/6J mice with CM-restricted overexpression of the dominant negative W-v mutant protein (dn-c-kit-Tg) respond to pressure overload with robust cardiomyocyte (CM) cell cycle entry. Here, we tested if outcomes after myocardial infarction (MI) due to coronary artery ligation are improved in this transgenic model. Compared to nontransgenic littermates (NTLs), adult male dn-c-kit-Tg mice displayed CM hypertrophy and concentric left ventricular (LV) hypertrophy in the absence of an increase in workload. Stroke volume and cardiac output were preserved and LV wall stress was markedly lower than that in NTLs, leading to a more energy-efficient heart. In response to MI, infarct size in adult (16-week old) dn-c-kit-Tg hearts was similar to that of NTL after 24 h but was half that in NTL hearts 12 weeks post-MI. Cumulative CM cell cycle entry was only modestly increased in dn-c-kit-Tg hearts. However, dn-c-kit-Tg mice were more resistant to infarct expansion, adverse LV remodelling and contractile dysfunction, and suffered no early death from LV rupture, relative to NTL mice. Thus, pre-existing cardiac hypertrophy lowers wall stress in dn-c-kit-Tg hearts, limits infarct expansion and prevents death from myocardial rupture.
资助项目	National Health and Medical Research Council of AustraliaNational Health and Medical Research Council of Australia [1012190, 573732, 1074386]; Heart Foundation of Australia grant [G10S 5148]; RT Hall Estate grant; Stem Cells Australia-the Australian Research Council Special Research Initiative in Stem Cell ScienceAustralian Research Council [SR110001002]; National Institute of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [HL079040, HL127726]; American Heart Association GrantAmerican Heart Association [13SDG16460006]; Leducq Transatlantic Network of Excellence in Cardiovascular Research grant; National Nature Science Foundation of China grantNational Natural Science Foundation of China (NSFC) [81670336]; NATIONAL HEART, LUNG, AND BLOOD INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Heart Lung & Blood Institute (NHLBI) [R01HL127726] Funding Source: NIH RePORTER
出版者	NATURE PUBLISHING GROUP
出版地	LONDON
ISSN	2045-2322
卷号	8 期号:1 页码:6114
DOI	10.1038/s41598-018-24525-6
页数	13
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
WOS记录号	WOS:000430177800014
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	29666426
PMC记录号	PMC5904135
SCOPUSEID	2-s2.0-85045763737
通讯作者地址	[Graham, Robert M.]Division of Molecular Cardiology and Biophysics,Victor Chang Cardiac Research Institute,Sydney,2010,Australia
Scopus学科分类	Multidisciplinary
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/10159
专题	基础医学院（机能实验教学中心）_基础医学研究中心_心脏再生医学研究所
通讯作者	Graham, Robert M.
作者单位	1.Division of Molecular Cardiology and Biophysics,Victor Chang Cardiac Research Institute,Sydney,2010,Australia; 2.St Vincent's Clinical School,University of New South Wales,Sydney,2052,Australia; 3.Cardiac Regeneration Research Institute,Wenzhou Medical University,Wenzhou,325035,China; 4.Epartment of Medicine,Emory University School of Medicine,Atlanta,30322,United States; 5.Department of Surgery,Emory University School of Medicine,Atlanta,30308,United States
推荐引用方式 GB/T 7714	Iismaa, Siiri E.,Li, Ming,Kesteven, Scott,et al. Cardiac hypertrophy limits infarct expansion after myocardial infarction in mice[J]. SCIENTIFIC REPORTS,2018,8(1):6114.
APA	Iismaa, Siiri E.., Li, Ming., Kesteven, Scott., Wu, Jianxin., Chan, Andrea Y.., ... & Graham, Robert M.. (2018). Cardiac hypertrophy limits infarct expansion after myocardial infarction in mice. SCIENTIFIC REPORTS, 8(1), 6114.
MLA	Iismaa, Siiri E.,et al."Cardiac hypertrophy limits infarct expansion after myocardial infarction in mice".SCIENTIFIC REPORTS 8.1(2018):6114.