Low local blood perfusion, high white blood cell and high platelet count are associated with primary tumor growth and lung metastasis in a 4T1 mouse breast cancer metastasis model

doi:10.3892/ol.2015.3304

科研成果详情

题名	Low local blood perfusion, high white blood cell and high platelet count are associated with primary tumor growth and lung metastasis in a 4T1 mouse breast cancer metastasis model
作者	Wang, Chuan 1; Chen, Ying-Ge 1; Gao, Jian-Li 1; Lyu, Gui-Yuan 1; Su, Jie 1; Zhang, Qi 2; Ji, Xin 3; Yan, Ji-Zhong 4; Qiu, Qiao-Li 1; Zhang, Yue-Li 2; Li, Lin-Zi2; Xu, Han-Ting 1; Chen, Su-Hong2
发表日期	2015-08
发表期刊	ONCOLOGY LETTERS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	circulate blood perfusion basophils thrombosis breast cancer lung metastasis
其他关键词	P-SELECTIN ; LYMPHOCYTE RATIO ; BASOPHILS ; INSIGHTS
摘要	It was originally thought that no single routine blood test result would be able to indicate whether or not a patient had cancer; however, several novel studies have indicated that the median survival and prognosis of cancer patients were markedly associated with the systemic circulation features of cancer patients. In addition, certain parameters, such as white blood cell (WBC) count, were largely altered in malignant tumors. In the present study, routine blood tests were performed in order to observe the change of blood cells in tumor-bearing mice following the implantation of 411 breast cancer cells into the mammary fat pad; in addition, blood flow in breast tumor sites was measured indirectly using laser Doppler perfusion imaging (LDPI), in an attempt to explain the relevance between the blood circulation features and the growth or metastasis of breast cancer in mice model. The LDPI and blood test results indicated that the implantation of 411 breast cancer cells into BALBic mice led to thrombosis as well as high WBC count, high platelet count, high plateletcrit and low blood perfusion. Following implantation of the 41'1 cells for four weeks, the lung metastatic number was determined and the Pearson correlation coefficient revealed that the number of visceral lung metastatic sites had a marked negative association with the ratio of basophils (BAS0%; r=-0.512; P<0.01) and the mean corpuscular hemoglobin was significantly correlated with primary tumor weight (r=0.425; P<0.05). In conclusion, the results of the present study demonstrated that tumor growth led to thrombosis and acute anemia in mice; in addition, when blood BASO% was low, an increased number of lung metastases were observed in tumor-bearing mice.
资助项目	National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81102852, 81473575, 81202972]; Zhejiang Provincial Key Laboratory Project [2012E10002]; Young Academic Leaders Project of High School in Zhejiang Province [pd2013208]
出版者	SPANDIDOS PUBL LTD
出版地	ATHENS
ISSN	1792-1074
EISSN	1792-1082
卷号	10 期号:2 页码:754-760
DOI	10.3892/ol.2015.3304
页数	7
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000358676200031
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	26622565
PMC记录号	PMC4509112
SCOPUSEID	2-s2.0-84931450579
通讯作者地址	[Gao, Jian-Li]Institute of Materia Medica,Zhejiang Chinese Medical University,548 Binwen Road,Binjiang, Hangzhou,310053,China
Scopus学科分类	Oncology;Cancer Research
引用统计	被引频次：32[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/10020
专题	第一临床医学院（信息与工程学院）、附属第一医院_中医学
通讯作者	Gao, Jian-Li
作者单位	1.Institute of Materia Medica,Zhejiang Chinese Medical University,Hangzhou,310053,China; 2.Institute of Chinese Medicine,Wenzhou Medical University,Wenzhou,325035,China; 3.Department of Pharmacology,School of Medicine,Zhejiang University,Hangzhou,310058,China; 4.College of Pharmaceutical Science,Zhejiang University of Technology,Hangzhou,310014,China
推荐引用方式 GB/T 7714	Wang, Chuan,Chen, Ying-Ge,Gao, Jian-Li,et al. Low local blood perfusion, high white blood cell and high platelet count are associated with primary tumor growth and lung metastasis in a 4T1 mouse breast cancer metastasis model[J]. ONCOLOGY LETTERS,2015,10(2):754-760.
APA	Wang, Chuan., Chen, Ying-Ge., Gao, Jian-Li., Lyu, Gui-Yuan., Su, Jie., ... & Chen, Su-Hong. (2015). Low local blood perfusion, high white blood cell and high platelet count are associated with primary tumor growth and lung metastasis in a 4T1 mouse breast cancer metastasis model. ONCOLOGY LETTERS, 10(2), 754-760.
MLA	Wang, Chuan,et al."Low local blood perfusion, high white blood cell and high platelet count are associated with primary tumor growth and lung metastasis in a 4T1 mouse breast cancer metastasis model".ONCOLOGY LETTERS 10.2(2015):754-760.